HUANG Yu Wen; JIAN Le; ZHANG Mei Bian; ZHOU Quan; YAN Xiao Feng; HUA Xu Dong; ZHOU Ying; HE Ji Liang

doi:10.3967/0895-3988.2012.01.016

doi: 10.3967/0895-3988.2012.01.016

基金项目: This research was supported by the Scientific Research Fund of Health Bureau in Zhejiang Province(2009A089)%Scientific Research Fund of Education Bureau in Zhejiang Province(Y200804934)

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

The Second Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou 310009, Zhejiang, China
School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth 6845,Australia
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Hangzhou 310020, Zhejiang, China
Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310012, Zhejiang, China
Zhejiang University, Medical College, Institute of Environmental Medicine, Hangzhou 310058, Zhejiang, China

Funds: This research was supported by the Scientific Research Fund of Health Bureau in Zhejiang Province(2009A089)%Scientific Research Fund of Education Bureau in Zhejiang Province(Y200804934)

摘要: Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group Ⅰ,Ⅱ,and control group Ⅰ,Ⅱ.Results 5-FU concentration ratios for gloves and masks in exposed group Ⅰ were significantly higher than those in exposed group Ⅱ (P＜0.05 or P＜0.01).The average urinary 8-OHdG concentrations in exposed group Ⅰ,control group Ⅰ,exposed group Ⅱ,and control group Ⅱ were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group Ⅰ was significantly higher than that in control group Ⅰ or that in exposed group Ⅱ (P＜0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P＜0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment.
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Abstract: Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group Ⅰ,Ⅱ,and control group Ⅰ,Ⅱ.Results 5-FU concentration ratios for gloves and masks in exposed group Ⅰ were significantly higher than those in exposed group Ⅱ (P＜0.05 or P＜0.01).The average urinary 8-OHdG concentrations in exposed group Ⅰ,control group Ⅰ,exposed group Ⅱ,and control group Ⅱ were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group Ⅰ was significantly higher than that in control group Ⅰ or that in exposed group Ⅱ (P＜0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P＜0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment.
- Urinary 8-OHdG /
- Oxidative DNA damage /
- Antineoplastic drugs /
- Occupational exposure /
- Pharmacy Intravenous Admixture Service

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doi: 10.3967/0895-3988.2012.01.016

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

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An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

doi: 10.3967/0895-3988.2012.01.016

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An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

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doi: 10.3967/0895-3988.2012.01.016

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

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An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

doi: 10.3967/0895-3988.2012.01.016

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An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

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