BAI Ya Na; MA Li; WANG Qiu Ying; PU Hong Quan; ZHANG Xiao Pei; WU Xi Jiang; XUAN Xiao Qiang

doi:10.3967/0895-3988.2013.07.018

The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

BAI Ya Na, MA Li, WANG Qiu Ying, PU Hong Quan, ZHANG Xiao Pei, WU Xi Jiang, XUAN Xiao Qiang

文章导航 > Biomedical and Environmental Sciences > 2013 > 26(7): 625-628

BAI Ya Na, MA Li, WANG Qiu Ying, PU Hong Quan, ZHANG Xiao Pei, WU Xi Jiang, XUAN Xiao Qiang. The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats[J]. Biomedical and Environmental Sciences, 2013, 26(7): 625-628. doi: 10.3967/0895-3988.2013.07.018

Citation:

BAI Ya Na, MA Li, WANG Qiu Ying, PU Hong Quan, ZHANG Xiao Pei, WU Xi Jiang, XUAN Xiao Qiang. The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats[J]. Biomedical and Environmental Sciences, 2013, 26(7): 625-628. doi: 10.3967/0895-3988.2013.07.018

doi: 10.3967/0895-3988.2013.07.018

The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000, Gansu, China;School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China
College of Earth and Environmental Science, Lanzhou University, Lanzhou 730000, Gansu, China
Hospital Workers of Jinchuan Company, Jinchuan Group Co.,Ltd., Jinchuan 737103, Gansu, China
Key Laboratory of Preclinical Study for New Medicine of Gansu Province, College of Basic Medicine, Lanzhou University, Lanzhou 730000, Gansu, China

摘要: Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure.As previously reported,nickel carbonyl can cause acute aspiration pneumonia,and animal experiments showed it was toxic to animal lung,liver,brain,and other vital organs[1].However,few studies have investigated nickel carbonyl poisoning in humans[2].Current research has mainly focused on the carcinogenicity of nickel carbonyl and therapy by nickel carbonyl inhibition at the cytochrome level[3].Nevertheless,there is still a lack of studies on the mechanism of nickel carbonyl poisoning and its toxic effects on gene expression and gene regulation.
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- gene regulation /
- gene expression /
- carbon monoxide

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The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

doi: 10.3967/0895-3988.2013.07.018

刊出日期: 2013-07-20

关键词:

gene regulation /

gene expression /

carbon monoxide

摘要: Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure.As previously reported,nickel carbonyl can cause acute aspiration pneumonia,and animal experiments showed it was toxic to animal lung,liver,brain,and other vital organs[1].However,few studies have investigated nickel carbonyl poisoning in humans[2].Current research has mainly focused on the carcinogenicity of nickel carbonyl and therapy by nickel carbonyl inhibition at the cytochrome level[3].Nevertheless,there is still a lack of studies on the mechanism of nickel carbonyl poisoning and its toxic effects on gene expression and gene regulation.