2018 Vol. 31, No. 5

2018-05cover


2019, 32(5): 1-1.
2018-05contents

2018, 31(5): 2-2.
Original Articles
Optical Coherence Tomography Features of Tuberculous Serpiginous-like Choroiditis and Serpiginous Choroiditis
WANG Xiao Na, YOU Qi Sheng, ZHAO Hui Ying, PENG Xiao Yan
2018, 31(5): 327-334. doi: 10.3967/bes2018.043
Objective To investigate optical coherence tomography (OCT) characteristics of tuberculous serpiginous-like choroiditis (Tb-SLC) and serpiginous choroiditis (SC) and to perform OCT to differentiate between these conditions. Methods This retrospective, case-control study examined consecutively enrolled patients with active Tb-SLC or SC. Patients underwent comprehensive ocular examinations and imaging (OCT, color fundus photography, autofluorescence imaging, fluorescein angiography, and indocyanine green angiography). Findings were examined and compared between eyes with SC and Tb-SLC. Results Nine patients with active Tb-SLC (14 eyes) and 8 with active SC (12 eyes) were included. The following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group:vitreal hyper-reflective spots [5 Tb-SLC eyes (36%), no SC eyes; P=0.02], intraretinal edema [11 Tb-SLC eyes (79%), 3 SC eyes (25%); P=0.01], sub-retinal pigment epithelium (RPE) drusenoid deposits [11 Tb-SLC eyes (79%), 2 SC eyes (17%); P < 0.01], and choroidal granulomas [8 Tb-SLC eyes (57%), 2 SC eyes (17%); P=0.03]. A hyporeflective, wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes (36%), 9 SC eyes (75%); P=0.045] than in the Tb-SLC group. The incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection, outer retinal tabulation, and choriocapillaris point-like hyper-reflection. Conclusion Vitreal hyper-reflective spots, intraretinal fluid, sub-RPE drusenoid deposits, and choroidal granulomas on OCT images may indicate Tb-SLC. Additionally, a hyporeflective, wedge-shaped band may indicate SC. Therefore, OCT is likely helpful in differentiating between Tb-SLC and SC.
Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions
Suni Lee, Shoko Yamamoto, Yasumitsu Nishimura, Hidenori Matsuzaki, Kei Yoshitome, Tamayo Hatayama, Miho Ikeda, YU Min, Nagisa Sada, Naoko Kumagai-Takei, Takemi Otsuki
2018, 31(5): 335-342. doi: 10.3967/bes2018.044
Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months 'Off to On' and 'On to Off' periods using negatively charged particle-dominant indoor air conditions (NCPDIAC). Methods Seven volunteers participated in the study, which included 'OFF to 3 months ON' periods (ON trials) for a total of 16 times, and 'ON to 3 months OFF' (OFF trials) periods for a total of 13 times. Results With the exception of one case, serum amyloid A (SAA) levels decreased significantly during the ON trials. Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein (CRP), this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes, since an increase in high-sensitive CRP is associated with the subsequent detection of these events.
Efficient Humoral and Cellular Immune Responses Induced by a Chimeric Virus-like Particle Displaying the Epitope of EV71 without Adjuvant
LIANG Pu, YI Yao, SU Qiu Dong, QIU Feng,