Common SNPs of APM1 Gene Are Not Associated With Hypertension or Obesity in Chinese Population
Abstract: Objective To investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity (HO) and related clinical features in Chinese Han population. Methods A case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were getotyped by PCR product sequencing in 484cases with HO and 502 controls with normal blood presure and BMI ＜ 25. Results The genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in T allele carriers than that in non-T carriers after adjusting possible confounding factors (1.21 vs 1.32 mmol/L, P=0.0001). Conclusion Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population. Common polymorphism of 45T/G might be associated with serum HDL-C levels in Chinese.
|Citation:||WEI-LI YAN, SHU-FENG CHEN, JIAN-FENG HUANG, YAN SHEN, Bo-QIN QIANG, DONG-HAI LIU, DONG-FENG GU. Common SNPs of APM1 Gene Are Not Associated With Hypertension or Obesity in Chinese Population[J]. Biomedical and Environmental Sciences, 2006, 19(3): 179-184.|