In Vitro Anti-HIV Activity of a Chinese Fungus Extract
Abstract: Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1. Results M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.
|Citation:||ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.|