Volume 19 Issue 3
Nov.  2019
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ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.
Citation: ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.

In Vitro Anti-HIV Activity of a Chinese Fungus Extract

Funds:  国家医药科学基金(2001BA705B01)%国家自然科学基金(30325047)
  • Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1. Results M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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In Vitro Anti-HIV Activity of a Chinese Fungus Extract

Funds:  国家医药科学基金(2001BA705B01)%国家自然科学基金(30325047)

Abstract: Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1. Results M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.

ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.
Citation: ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.

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