2013 Vol. 26, No. 12

The Impact of Haze Weather on Health:A view to Future
LU Kai, QIN Yu, HE Guang Xue, George F.GAO
2013, 26(12): 945-946. doi: 10.3967/bes2013.028
Research Highlight
The Impact of Cigarette Smoking on Metabolic Syndrome
JIA Wei Ping
2013, 26(12): 947-951. doi: 10.3967/bes2013.029
Original Articles
Artesunate Effect on Schistosome Thioredoxin Glutathione Reductase and Cytochrome c Peroxidase as New Molecular Targets in Schistosoma mansoni-infected Mice
Amany A.Abdin, Dalia S.Ashour, Zeinab S.Shoheib
2013, 26(12): 953-961. doi: 10.3967/bes2013.030
Objective To investigate the possible effect of artesunate (ART) on schistosome thioredoxin glutathione reductase (TGR) and cytochrome c peroxidase (CcP) in Schistosoma mansoni-infected mice.
Methods A total of 200 laboratory bred male Swiss albino mice were divided into 4 groups (50 mice in each group). Group I:infected untreated group (Control group) received a vehicle of 1%sodium carbonyl methylcellulose (CMC-Na); Group II: infected then treated with artesunate; Group III: infected then treated with praziquantel, and group IV:infected then treated with artesunate then praziquantel. Adult S. mansoni worms were collected by Animal Perfusion Method, tissue egg counted, TGR, and CcP mRNA Expression were estimated of in S. mansoni adult worms by semi-quantitative rt-PCR.
Results Semi-quantitative rt-PCR values revealed that treatment with artesunate caused significant decrease in expression of schistosome TGR and CcP in comparison to the untreated group. In contrast, the treatment with praziquantel did not cause significant change in expression of these genes. The results showed more reduction in total worm and female worm count in combined ART-PZQ treated group than in monotherapy treated groups by either ART or PZQ. Moreover, complete disappearance (100%) of tissue eggs was recorded in ART-PZQ treated group with a respective reduction rate of 95.9%and 68.4%in ART-and PZQ-treated groups.
Conclusion The current study elucidated for the first time that anti-schistosomal mechanisms of artesunate is mediated via reduction in expression of schistosome TGR and CcP. Linking these findings, addition of artesunate to praziquantel could achieve complete cure outcome in treatment of schistosomiasis.
Co-effect of Demand-control-support Model and Effort-reward Imbalance Model on Depression Risk Estimation in Humans:Findings from Henan Province of China
YU Shan Fa, NAKATA Akinori, GU Gui Zhen, SWANSON Naomi G, ZHOU Wen Hui, HE Li Hua, WANG Sheng
2013, 26(12): 962-971. doi: 10.3967/bes2013.031
Objective To investigate the co-effect of Demand-control-support (DCS) model and Effort-reward Imbalance (ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively.
Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire (Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale (CES-D).
Results DC (demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support (SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone. ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively.
Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans.
Spatio-temporal Evolution on Geographic Boundaries of HFRS Endemic Areas in Shandong Province, China
LIU Yan Xun, WANG Zhi Qiang, GUO Jing, TANG Fang, SUN Xiu Bin, XUE Fu Zhong, KANG Dian Min
2013, 26(12): 972-978. doi: 10.3967/bes2013.032
Objective To take effective strategies and measures for the prevention and control of hemorrhagic fever with renal syndrome (HFRS) endemic areas by investigating its dynamic geographical boundaries in Shandong Province, China.
Methods The incidence of HFRS from 1982 to 2008 in Shandong Prvince, China, was detected with inverse distance weighting (IDW) interpolation based on geographical information system (GIS). Dynamic geographical boundaries of HFRS endemic areas in Shandong Province, China, were analyzed by geographical boundary analysis.
Results The HTN-type endemic areas of HFRS were located in Linyi City in phase 1 (1982-1986), the SEO-type endemic areas of HFRS were located in Jining City in phase 2 (1987-2003), and the endemic areas of HFRS in Jining City gradually disappeared and the endemic areas of HFRS with mixed-types of reservoir rodents were located in Linyi City in phase 3 (2004-2008). Meanwhile, new endemic areas emerged in the northwestern Shandong province, China.
Conclusion The SEO-type endemic areas of HFRS are located in western Shandong Province, China, and the HTN-type endemic areas of HFRS are located eastern Shandong Province, Chin, indicating that the endemic areas of HFRS should be vaccinated and rodents should be controlled.
Role of Insulin-like Growth Factor II Receptor in Transdifferentiation of Free Silica-induced Primary Rat Lung Fibroblasts
HAO Chang Fu, LI Xiao Fang, YAO Wu
2013, 26(12): 979-985. doi: 10.3967/bes2013.033
Objective To study the role of insulin-like growth factor II receptor in free silica-induced transdifferentiation of primary rat lung fibroblasts
Methods Rat lung fibroblasts and rat alveolar macrophages were cultured. A transdifferentiation model of primary rat lung fibroblasts was induced by free silica. Levels ofα-SMA protein, IGF-IIR protein and mRNA were measured by immunocytochemistry, Western blot and RT-PCR, respectively. Lung fibroblasts were treated with Wortmannin.
Results The expression levels of α-SMA and IGF-IIR increased with the increasing free silica concentration and decreased after Wortmannin was used.
Conclusion The IGF-IIR plays an important role in free silica-induced transdifferentiation of primary rat lung fibroblasts.
Letters to the Editor
Effects of Low Concentrations of Di-(2-ethylhexyl) and Mono-(2-ethylhexyl) Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC-1
CHEN Xi, LIU Ya Nan, ZHOU Qing Hong, LENG Ling, CHANG Ying, TANG Nai Jun
2013, 26(12): 986-989. doi: 10.3967/bes2013.034
Mitochondria DNA 4 977 bp Common Deletion in Peripheral Whole Blood from Healthy Donors
WANG Ping, LIU Yu Long, HAN Lin, ZHAO Feng Ling, GUO Fei, WANG Xi Ai, LV Yu Min
2013, 26(12): 990-993. doi: 10.3967/bes2013.035
Dengue Fever Epidemiological Status and Relationship with Meteorological Variables in Guangzhou, Southern China, 2007-2012
LI Tie Gang, YANG Zhi Cong, LUO Lei, DI Biao, WANG Ming
2013, 26(12): 994-997. doi: 10.3967/bes2013.036
Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation
GAO Hui, XU Xiao Shuang, CHEN Ze Dong, ZHANG Quan, XU Xiang Ming
2013, 26(12): 998-1002. doi: 10.3967/bes2013.037
Characterization of Class 1 Integron Gene Cassettes among Clinical Bacteria Isolated from One Large Hospital in Northern China
CHEN Xia, LI Gui Xi, ZHANG Hong, YUAN Min, HOU Xiao Ping, YU Hui Lan, LI Juan
2013, 26(12): 1003-1007. doi: 10.3967/bes2013.038
Serum Folate, MTHFR C677T Polymorphism and Esophageal Squamous Cell Carcinoma Risk
HUANG Gui Ling, WANG Shao Kang, SU Ming, WANG Ting Ting, CAI Hui Zhen, YIN Hong, SUN Gui Ju
2013, 26(12): 1008-1012. doi: 10.3967/bes2013.039