Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China

ZHU JingYuan DUAN GuangCai YANG HaiYan FAN QingTang XI YuanLin

ZHU JingYuan, DUAN GuangCai, YANG HaiYan, FAN QingTang, XI YuanLin. Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China[J]. Biomedical and Environmental Sciences, 2011, 24(1): 56-61. doi: 10.3967/0895-3988.2011.01.007
Citation: ZHU JingYuan, DUAN GuangCai, YANG HaiYan, FAN QingTang, XI YuanLin. Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China[J]. Biomedical and Environmental Sciences, 2011, 24(1): 56-61. doi: 10.3967/0895-3988.2011.01.007

doi: 10.3967/0895-3988.2011.01.007
基金项目: the Research Fund from Ministry of Health of the People's Republic of China(WKJ2007-2-024)

Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China

Funds: the Research Fund from Ministry of Health of the People's Republic of China(WKJ2007-2-024)
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  • 刊出日期:  2011-02-20

Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China

doi: 10.3967/0895-3988.2011.01.007
    基金项目:  the Research Fund from Ministry of Health of the People's Republic of China(WKJ2007-2-024)

摘要: Objective To investigate the characteristic of integrons and the relationship between integrons and antimicrobial resistance in Shigellaspp.Methods Ninety 5higella strains (83 S. flexneri and 7 S. sonnel) were isolated from the stools of patients in China. Susceptibility to 8 antimicrobials was tested for all isolated strains. PCR, RFLP and sequencing analysis of integrons were applied to all of them.Results High prevalence of multi-drug resistance (95.6%) was identified. Of the isolates 79 (87.8%)carried integrase genes of class 1 integron (3.3%), class 2 integron (10.0%) or both (74.4%). No intβ was detected in the tested isolates. The prevalence of intΩ was significantly higher in isolates with multi-drug resistance to at least 3 antibiotics than that in isolates with resistance to 2 and less antibiotics (P<0.05). Gene cassettes dfrA17-aadAS, dfrA12-orfF-aadA2 of class 1 integron and dfrA1-sat1-aadA1 of class 2 integron were identified.Conclusion The class 2 integron may play a role in the emergence of multi-drug resistance in Shigella spp.

English Abstract

ZHU JingYuan, DUAN GuangCai, YANG HaiYan, FAN QingTang, XI YuanLin. Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China[J]. Biomedical and Environmental Sciences, 2011, 24(1): 56-61. doi: 10.3967/0895-3988.2011.01.007
Citation: ZHU JingYuan, DUAN GuangCai, YANG HaiYan, FAN QingTang, XI YuanLin. Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China[J]. Biomedical and Environmental Sciences, 2011, 24(1): 56-61. doi: 10.3967/0895-3988.2011.01.007

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