Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

PAN ShangXia YANG XingFen YANG LinQing WEI Qing YANG Ying XU GuangNing LIN ZhongNing HUANG JunMing

PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
Citation: PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006

doi: 10.3967/0895-3988.2011.05.006
基金项目: This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China

Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

Funds: This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China
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  • 刊出日期:  2011-10-20

Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

doi: 10.3967/0895-3988.2011.05.006
    基金项目:  This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China

摘要: Objective To investigate the associations of genetic polymorphisms in GSTs genes of the Hakka population of south China with family histories of certain chronic diseases.Methods Five hundred and thirty-nine healthy Hakka natives of Meizhou city of Guangdong province in south China were involved.The genotypes of GSTM1,GSTT1,GSTP1,GSTM3,and GSTA1 were determined using PCR and restriction fragment length polymorphism analysis.The observed polymorphisms were analyzed by Chi-square and Hardy-Weinberg equilibrium tests.Logistic regression analysis was used to determine the associations of the distributions of GST genotypes with family history of certain chronic diseases.Results The distributions of polymorphisms in GSTP1,GSTM3,and GSTA1 conformed to the Hardy-Weinberg equilibrium.Compared to the Cantonese,the Hakka had a lower distribution of the GSTM3 deletion genotype (3.15% vs.11.9%).A weak association was observed between the GSTM1 genetic polymorphism and family history of hypertension.Alcohol drinkers had a higher frequency of the null-GSTM1 genotype,while smokers had a higher frequency of a variant GSTP1 genotype.Conclusion The results suggest that the Hakka is a special and distinctive Han Chinese ethnic group with different GSTs genetic polymorphisms.Smoking and drinking might be related to the distribution of GST genotypes.

English Abstract

PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
Citation: PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006

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