Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

PAN ShangXia,  YANG XingFen,  YANG LinQing,  WEI Qing,  YANG Ying,  XU GuangNing,  LIN ZhongNing,  HUANG JunMing

downloadPDF
文章导航 > Biomedical and Environmental Sciences  > 2011 >  24(5): 491-498
PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
Citation: PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
shu

doi: 10.3967/0895-3988.2011.05.006
  • , 
  • , 
  • , 
  • , 
  • , 
  • , 
  • , 
基金项目: This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China

Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

  • Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 510300, Guangdong, China

  • School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China

Funds: This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China

WeChat 点击查看大图
计量
  • 文章访问数:  1175
  • HTML全文浏览量:  314
  • PDF下载量:  42
  • 被引次数: 0
出版历程
  • 刊出日期:  2011-10-20

Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases

doi: 10.3967/0895-3988.2011.05.006
    基金项目:  This research was supported by grants from the Team Project of Guangdong Province National Science Fund(NO.015042)%the Research Fund of Center for Disease Control and Prevention of Guangdong (GDCDC) Province,China
  • 刊出日期: 2011-10-20

摘要: Objective To investigate the associations of genetic polymorphisms in GSTs genes of the Hakka population of south China with family histories of certain chronic diseases.Methods Five hundred and thirty-nine healthy Hakka natives of Meizhou city of Guangdong province in south China were involved.The genotypes of GSTM1,GSTT1,GSTP1,GSTM3,and GSTA1 were determined using PCR and restriction fragment length polymorphism analysis.The observed polymorphisms were analyzed by Chi-square and Hardy-Weinberg equilibrium tests.Logistic regression analysis was used to determine the associations of the distributions of GST genotypes with family history of certain chronic diseases.Results The distributions of polymorphisms in GSTP1,GSTM3,and GSTA1 conformed to the Hardy-Weinberg equilibrium.Compared to the Cantonese,the Hakka had a lower distribution of the GSTM3 deletion genotype (3.15％ vs.11.9％).A weak association was observed between the GSTM1 genetic polymorphism and family history of hypertension.Alcohol drinkers had a higher frequency of the null-GSTM1 genotype,while smokers had a higher frequency of a variant GSTP1 genotype.Conclusion The results suggest that the Hakka is a special and distinctive Han Chinese ethnic group with different GSTs genetic polymorphisms.Smoking and drinking might be related to the distribution of GST genotypes.

English Abstract

PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
Citation: PAN ShangXia, YANG XingFen, YANG LinQing, WEI Qing, YANG Ying, XU GuangNing, LIN ZhongNing, HUANG JunMing. Human GSTs Polymorphisms in the Hakka Population of South China and Their Associations with Family History of Several Chronic Diseases[J]. Biomedical and Environmental Sciences, 2011, 24(5): 491-498. doi: 10.3967/0895-3988.2011.05.006
shu

    全文HTML

目录

    /

    返回文章
    返回

    Biomedical and Environmental Sciences ISSN 0895-3988 CN 11-2816 / Q

    Publish Under the Auspices of Chinese Center for Disease Control and Prevention

    Distributed by Chinese Center for Disease Control and Prevention

    All Rights Reserved by Chinese Center for Disease Control and Prevention 京ICP备11024750-4

    Quick Links

    Supported by Beijing Renhe Information Technology Co. Ltd E-mail: info@rhhz.net 百度统计