HUANG Yu Wen; JIAN Le; ZHANG Mei Bian; ZHOU Quan; YAN Xiao Feng; HUA Xu Dong; ZHOU Ying; HE Ji Liang

doi:10.3967/0895-3988.2012.01.016

doi: 10.3967/0895-3988.2012.01.016

基金项目: This research was supported by the Scientific Research Fund of Health Bureau in Zhejiang Province(2009A089)%Scientific Research Fund of Education Bureau in Zhejiang Province(Y200804934)

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

The Second Affiliated Hospital of College of Medicine of Zhejiang University, Hangzhou 310009, Zhejiang, China
School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth 6845,Australia
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University, Hangzhou 310020, Zhejiang, China
Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310012, Zhejiang, China
Zhejiang University, Medical College, Institute of Environmental Medicine, Hangzhou 310058, Zhejiang, China

Funds: This research was supported by the Scientific Research Fund of Health Bureau in Zhejiang Province(2009A089)%Scientific Research Fund of Education Bureau in Zhejiang Province(Y200804934)

摘要: Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group Ⅰ,Ⅱ,and control group Ⅰ,Ⅱ.Results 5-FU concentration ratios for gloves and masks in exposed group Ⅰ were significantly higher than those in exposed group Ⅱ (P＜0.05 or P＜0.01).The average urinary 8-OHdG concentrations in exposed group Ⅰ,control group Ⅰ,exposed group Ⅱ,and control group Ⅱ were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group Ⅰ was significantly higher than that in control group Ⅰ or that in exposed group Ⅱ (P＜0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P＜0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment.
- /
- /
- /
- /
Abstract: Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group Ⅰ,Ⅱ,and control group Ⅰ,Ⅱ.Results 5-FU concentration ratios for gloves and masks in exposed group Ⅰ were significantly higher than those in exposed group Ⅱ (P＜0.05 or P＜0.01).The average urinary 8-OHdG concentrations in exposed group Ⅰ,control group Ⅰ,exposed group Ⅱ,and control group Ⅱ were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group Ⅰ was significantly higher than that in control group Ⅰ or that in exposed group Ⅱ (P＜0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P＜0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment.
- Urinary 8-OHdG /
- Oxidative DNA damage /
- Antineoplastic drugs /
- Occupational exposure /
- Pharmacy Intravenous Admixture Service

[1]	Weizhao Cao, Yiming Zheng, Wenxuan Zhao, Lisha Shi, Yunhui Zhang, Lijun Zhang, Jian Chen. Health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai . Biomedical and Environmental Sciences, 2024, 37(8): 865-875. doi: 10.3967/bes2024.082
[2]	PAN Dong, DU Ya Rong, LI Rong, SHEN Ai Hua, LIU Xiao Dong, LI Chuan Yuan, HU Bu Rong. SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas . Biomedical and Environmental Sciences, 2022, 35(3): 194-205. doi: 10.3967/bes2022.028
[3]	JIN Nan, ZHONG Hui Yun, YUAN Fang, DENG Hua Xin. Positive Associations between Bilateral High-Frequency Hearing Loss and Hypertension Risk in Short-Term Occupational Noise Exposure . Biomedical and Environmental Sciences, 2021, 34(12): 992-997. doi: 10.3967/bes2021.134
[4]	GUO Qi Shan, RUAN Ping, HUANG Wei Xu, HUANG Dai Zheng, QIU Jia Chu. Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers . Biomedical and Environmental Sciences, 2021, 34(4): 282-289. doi: 10.3967/bes2021.037
[5]	Zlatko Zimet, Marjan Bilban, Teja Fabjan, Kristina Suhadolc, Borut Poljšak, Joško Osredkar. Lead Exposure and Oxidative Stress in Coal Miners . Biomedical and Environmental Sciences, 2017, 30(11): 841-845. doi: 10.3967/bes2017.113
[6]	DING Chun Guang, WANG Huan Qiang, SONG Han Bo, LI Zhi Hui, LI Xiao Ping, YE Shao Se, ZHANG Fu Gang, CUI Shi Wei, YAN Hui Fang, LI Tao. Occupational Exposure to Indium of Indium Smelter Workers . Biomedical and Environmental Sciences, 2016, 29(5): 379-384. doi: 10.3967/bes2016.049
[7]	YANG Ai Min, CHENG Ning, PU Hong Quan, LIU Si Min, LI Juan Sheng, BASSIG Bryan A., DAI Min. Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers . Biomedical and Environmental Sciences, 2015, 28(12): 875-883. doi: 10.3967/bes2015.121
[8]	LU Jie, ZHANG Jing, WANG Zhu Tian, FAN Yong Xiang. An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories . Biomedical and Environmental Sciences, 2014, 27(6): 419-425. doi: 10.3967/bes2014.071
[9]	XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng. Establishment of Occupational Exposure Limit for Warfarin in China . Biomedical and Environmental Sciences, 2013, 26(6): 513-516. doi: 10.3967/0895-3988.2013.06.015
[10]	SUN XiaoMing, LIU YeWei, WANG ZhenQuan, LI HongBing, LIU Yun, DI DuoLong. Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine . Biomedical and Environmental Sciences, 2011, 24(3): 222-227. doi: 10.3967/0895-3988.2011.03.003
[11]	ZHI-QING LIN, ZHU-GE XI, DAN-FENG YANG, FU-HUAN CHAO, HUA-SHAN ZHANG, WEI ZHANG, HUANG-LIANG LIU, ZAI-MING YANG, RU-BAO SUN. Oxidative Damage to Lung Tissue and Peripheral Blood in Endotracheal PM2.5-treated Rats . Biomedical and Environmental Sciences, 2009, 22(3): 223-228.
[12]	JIANG YUE, PENG WANG, YING-HUI LIU, JUN-YU WU, JIE CHEN, REN-XIU PENG. Fast Evaluation of Oxidative DNA Damage by Liquid Chromatography-Electropray Tandem Mass Spectrometry Coupled With Precision-Cut Rat Liver Slices . Biomedical and Environmental Sciences, 2007, 20(5): 386-391.
[13]	HONG-ZHI PAN, DONG CHANG, LEI-GUANG FENG, FENG-JUAN XU, HONG-YU KUANG, MING-JUN LU. Oxidative Damage to DNA and Its Relationship With Diabetic Complications . Biomedical and Environmental Sciences, 2007, 20(2): 160-163.
[14]	XIAO-HONG ZHAO, GUANG JIA, YONG-QUAN LIU, SHAO-WEI LIU, LEI YAN, YU JIN, NIAN LIU. Association Between Polymorphisms of DNA Repair Gene XRCC1 and DNA Damage in Asbestos-Exposed Workers . Biomedical and Environmental Sciences, 2006, 19(3): 232-238.
[15]	K.KRISHNAMURTHI, S. SARAVANA DEVI, T. CHAKRABARTI. DNA Damage Caused By Pesticide-contaminated Soil . Biomedical and Environmental Sciences, 2006, 19(6): 427-431.
[16]	ZHU-GE XI, FU-HUAN CHAO, DAN-FENG YANG, HUA-SHAN ZHANG, WEI ZHANG. 8-Hydroxydeoxyguanosine as a Biomarker of Oxidative DNA Damage Induced by Environmental Tobacco Side-stream Smoke and Its Mechanism . Biomedical and Environmental Sciences, 2005, 18(1): 43-47.
[17]	JUN-FU ZHOU, WEN ZHOU, SHU-MEI ZHANG, YAN-ER LUO, Huai-Hong Chen. Oxidative Stress and Free Radical Damage in Patients With Acute Dipterex Poisoning . Biomedical and Environmental Sciences, 2004, 17(2): 223-233.
[18]	AI-GUO WANG, TAO Xia, QI-LONG CHU, Ming Zhang, FANG LIU, XUE-MIN CHEN, KE-DI YANG. Effects of Fluoride on Lipid Peroxidation, DNA Damage and Apoptosis in Human Embryo Hepatocytes . Biomedical and Environmental Sciences, 2004, 17(2): 217-222.
[19]	QING-WEN MA, GUO-FANG LIN, JI-GANG CHEN, CUI-QING XIANG, WEI-CHAO GUO, KLAUS GOLKA, Jian-Hua SHEN. Polymorphism of N-acetyltransferase 2 (NAT2) Gene Polymorphism in Shanghai population:Occupational and Non-occupational Bladder Cancer Patient Groups . Biomedical and Environmental Sciences, 2004, 17(3): 291-298.
[20]	YANG Dong-Ping, XU Shi-jie, WANG JIAN-XIN. Study on Chromosome Damage Among Nurses Occupationally Exposed to Antineoplastic Drugs in an Oncology Department . Biomedical and Environmental Sciences, 2002, 15(3): 268-270.

点击查看大图

计量

文章访问数: 2792
HTML全文浏览量: 560
PDF下载量: 178
被引次数: 0

doi: 10.3967/0895-3988.2012.01.016

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

计量

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

doi: 10.3967/0895-3988.2012.01.016

English Abstract

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

全文HTML

目录

doi: 10.3967/0895-3988.2012.01.016

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

计量

出版历程

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

doi: 10.3967/0895-3988.2012.01.016

English Abstract

An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay

全文HTML

目录