Establishment of Occupational Exposure Limit for Warfarin in China

XU Jian Ning; FU Zhao Hui; YU Wen Lan; WANG Quan Kai; TAN Feng

doi:10.3967/0895-3988.2013.06.015

XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng

文章导航 > Biomedical and Environmental Sciences > 2013 > 26(6): 513-516

XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng. Establishment of Occupational Exposure Limit for Warfarin in China[J]. Biomedical and Environmental Sciences, 2013, 26(6): 513-516. doi: 10.3967/0895-3988.2013.06.015

引用本文:

Citation:

XU Jian Ning, FU Zhao Hui, YU Wen Lan, WANG Quan Kai, TAN Feng. Establishment of Occupational Exposure Limit for Warfarin in China[J]. Biomedical and Environmental Sciences, 2013, 26(6): 513-516. doi: 10.3967/0895-3988.2013.06.015

Establishment of Occupational Exposure Limit for Warfarin in China

doi: 10.3967/0895-3988.2013.06.015

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;
2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Establishment of Occupational Exposure Limit for Warfarin in China

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;
2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

摘要:
This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.

Abstract:
This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.

[1]	Lei Li, Lin Luo, Junnai Wang, Ying Hong, Jianfang Geng. Multivariate Analysis of Female Stress Urinary Incontinence and Establishment of a Prediction Model . Biomedical and Environmental Sciences, 2024, 37(8): 931-935. doi: 10.3967/bes2024.114
[2]	CHEN Xi, HAN Chao, ZHAO Jin Peng, SHEN Shi, WANG Li Yuan, REN Shou, WANG Tong Lei, MA Yan, XU Ze Chao, HUO Jun Sheng. Establishment of an Iron Deficiency Model by Iron Depletion in Pregnant Rats . Biomedical and Environmental Sciences, 2024, 37(2): 210-215. doi: 10.3967/bes2024.022
[3]	HE La Gu, LIANG Yun Lai, YANG Lu Qi, YUAN Hua Min. Prognostic Nutritional Index Associates with the Severity of Silicosis: A Study from a Tertiary Class A Prevention and Treatment Institute for Occupational Diseases in China . Biomedical and Environmental Sciences, 2024, 37(1): 122-126. doi: 10.3967/bes2024.012
[4]	ZHANG Yi Fan, MA Yu Xia, LI He Ping, CHENG Bo Wen, FENG Feng Liu, JIAO Hao Ran. Short-term exposure to ozone and nonaccidental mortality in Northeast China . Biomedical and Environmental Sciences, 2023, 36(1): 99-102. doi: 10.3967/bes2023.010
[5]	WANG Hui, MAO Wei Feng, JIANG Ding Guo, LIU Si Jie, ZHANG Lei. Cumulative Risk Assessment of Exposure to Heavy Metals through Aquatic Products in China . Biomedical and Environmental Sciences, 2021, 34(8): 606-615. doi: 10.3967/bes2021.084
[6]	JIN Nan, ZHONG Hui Yun, YUAN Fang, DENG Hua Xin. Positive Associations between Bilateral High-Frequency Hearing Loss and Hypertension Risk in Short-Term Occupational Noise Exposure . Biomedical and Environmental Sciences, 2021, 34(12): 992-997. doi: 10.3967/bes2021.134
[7]	GUO Qi Shan, RUAN Ping, HUANG Wei Xu, HUANG Dai Zheng, QIU Jia Chu. Occupational Radiation Exposure and Changes in Thyroid Hormones in a Cohort of Chinese Medical Radiation Workers . Biomedical and Environmental Sciences, 2021, 34(4): 282-289. doi: 10.3967/bes2021.037
[8]	CUI Liang Liang, ZHOU Jing Wen, GENG Xing Yi, LI Xin Wei, LIU Zhong, George A. Conway, ZHANG Ji. Occupational Carbon Monoxide Poisoning Associated with Diesel Motor Operation in an Air-raid Shelter in June 2015, Jinan City, China—An Epidemiological Investigation . Biomedical and Environmental Sciences, 2017, 30(10): 777-781. doi: 10.3967/bes2017.105
[9]	ZHOU Li Fang, TIAN Fang, ZOU Hua, YUAN Wei Ming, HAO Mo, ZHANG Mei Bian. Research Progress in Occupational Health Risk Assessment Methods in China . Biomedical and Environmental Sciences, 2017, 30(8): 616-622. doi: 10.3967/bes2017.082
[10]	ZHANG Lei, JIANG Ding Guo, SUI Hai Xia, WU Ping Gu, LIU Ai Dong, YANG Da Jin, LIU Zhao Ping, SONG Yan, LI Ning. Dietary Exposure to Benzyl Butyl Phthalate in China . Biomedical and Environmental Sciences, 2016, 29(5): 365-373. doi: 10.3967/bes2016.047
[11]	DING Chun Guang, WANG Huan Qiang, SONG Han Bo, LI Zhi Hui, LI Xiao Ping, YE Shao Se, ZHANG Fu Gang, CUI Shi Wei, YAN Hui Fang, LI Tao. Occupational Exposure to Indium of Indium Smelter Workers . Biomedical and Environmental Sciences, 2016, 29(5): 379-384. doi: 10.3967/bes2016.049
[12]	YANG Ai Min, CHENG Ning, PU Hong Quan, LIU Si Min, LI Juan Sheng, BASSIG Bryan A., DAI Min. Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers . Biomedical and Environmental Sciences, 2015, 28(12): 875-883. doi: 10.3967/bes2015.121
[13]	CHEN Li, CAO Dan, LI Lu Xi, ZHAO Yan, XIE Chang Ming, ZHANG Yun Hui. Assessment of Exposure to Polybrominated Dipheny Ethers via Inhalation and Diet in China . Biomedical and Environmental Sciences, 2014, 27(11): 872-882. doi: 10.3967/bes2014.124
[14]	ZHOU Xin, HOU Xue Xia, GENG Zhen, ZHAO Rui, WAN Kang Lin, HAO Qin. Establishment of Multiple Locus Variable-number Tandem Repeat Analysis Assay for Genotyping of Borrelia burgdorferi sensu lato Detected in China . Biomedical and Environmental Sciences, 2014, 27(9): 665-675. doi: 10.3967/bes2014.102
[15]	SUN XiaoMing, LIU YeWei, WANG ZhenQuan, LI HongBing, LIU Yun, DI DuoLong. Effect of Occupational Manganese Exposure on Uric Acid Levels in Human Urine . Biomedical and Environmental Sciences, 2011, 24(3): 222-227. doi: 10.3967/0895-3988.2011.03.003
[16]	Aleksandra POPOV, Ivana MIRKOV, Lidija ZOLOTAREVSKI, Milena JOVIC, Sandra BELIJ, Dragan KATARANOVSKI, Milena KATARANOVSKI. Local Proinflammatory Effects of Repeated Skin Exposure to Warfarin, An Anticoagulant Rodenticide in Rats . Biomedical and Environmental Sciences, 2011, 24(2): 180-189. doi: 10.3967/0895-3988.2011.02.013
[17]	Lin XIAO, Yan YANG, Qiang LI, Cong-Xiao WANG, Gong-Huan YANG. Population-Based Survey of Secondhand Smoke Exposure in China . Biomedical and Environmental Sciences, 2010, 23(6): 430-436.
[18]	CHOU-FEI WU, YANG XU, YONG TAO, JI-YAN YANG. Establishment of Hypoglycemic Agent Screening Method Based on Human Glucokinase . Biomedical and Environmental Sciences, 2009, 22(1): 62-69.
[19]	BO SHAO, TAI-YI JIN, XUN-WEI WU, QING-HU KONG, TING-TING YE. Application of Benchmark Dose (BMD) in Estimating Biological Exposure Limit (BEL) to Cadmium . Biomedical and Environmental Sciences, 2007, 20(6): 460-464.
[20]	HAI-DONG KAN, BING-HENG CHEN, CHANG-HONG CHEN, BING-YAN WANG, QING-YAN FU. Establishment of Exposure-response Functions of Air Particulate Matter and Adverse Health Outcomes in China and Worldwide . Biomedical and Environmental Sciences, 2005, 18(3): 159-163.

点击查看大图

计量

文章访问数: 1414
HTML全文浏览量: 411
PDF下载量: 34
被引次数: 0

Establishment of Occupational Exposure Limit for Warfarin in China

doi: 10.3967/0895-3988.2013.06.015

1.National Institute of Occupational Health and Poison Control, Chinese Centers for Disease Control and Prevention, Beijing 100050, China;

2. Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China

刊出日期: 2013-06-20

摘要:

This study aims to establish the occupational exposure limit (OEL) in the air for workplace of warfarin based on the available toxicological studies and field investigations by using questionnaire and air monitoring. The clinical therapeutic dose was used as lowest observed effect level (LOEL), and no observed effect level (NOEL) was achieved by using a safety factor. The highest concentration of warfarin monitored in the worksite of centrifuge washing, drying and packing were 0.029 mg/m3, 0.051 mg/m3 respectively, which did not exceed the OEL 0.1 mg/m3 recommended by NIOSH and ACGIH. Considering its feasibility for enforcement and protection for workers, we recommend OEL 0.1 mg/m3 of warfarin in China.