SONG Yang; JIA Zhen Chao; CHEN Jin Yao; HU Jun Xiang; ZHANG Li Shi

doi:10.3967/bes2014.050

Toxic Effects of Atrazine on Reproductive System of Male Rats

SONG Yang, JIA Zhen Chao, CHEN Jin Yao, HU Jun Xiang, ZHANG Li Shi

文章导航 > Biomedical and Environmental Sciences > 2014 > 27(4): 281-288

SONG Yang, JIA Zhen Chao, CHEN Jin Yao, HU Jun Xiang, ZHANG Li Shi. Toxic Effects of Atrazine on Reproductive System of Male Rats[J]. Biomedical and Environmental Sciences, 2014, 27(4): 281-288. doi: 10.3967/bes2014.050

Citation:

SONG Yang, JIA Zhen Chao, CHEN Jin Yao, HU Jun Xiang, ZHANG Li Shi. Toxic Effects of Atrazine on Reproductive System of Male Rats[J]. Biomedical and Environmental Sciences, 2014, 27(4): 281-288. doi: 10.3967/bes2014.050

doi: 10.3967/bes2014.050

基金项目: National Natural Science Foundation of China(81030053)%National High-technology R esearch and Development Program (‘863’ program) of China(2010AA023001)

Toxic Effects of Atrazine on Reproductive System of Male Rats

Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan, China

Funds: National Natural Science Foundation of China(81030053)%National High-technology R esearch and Development Program (‘863’ program) of China(2010AA023001)

摘要: Objective This study was designed to evaluate the toxic effects of Atrazine (ATZ) on the reproductive system of male rats.
Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels.
Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group;a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups;decreased levels of acid phosphatase (ACP), alkaline phosphatase (AKP), lactic dehydrogenase (LDH), and succinate dehydrogenase (SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity (TAC) in a dose-dependent manner, and a decreased reduced glutathione (GSH) level and an increased malondialdehyde (MDA) content in 154 mg/kg group;and decreased serum levels of testosterone (T) and inhibin-B (INH-B) and an increased serum level of follicle stimulating hormone (FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone (LH) in 154 mg/kg group.
Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats.
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Abstract: Objective This study was designed to evaluate the toxic effects of Atrazine (ATZ) on the reproductive system of male rats.
Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels.
Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group;a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups;decreased levels of acid phosphatase (ACP), alkaline phosphatase (AKP), lactic dehydrogenase (LDH), and succinate dehydrogenase (SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity (TAC) in a dose-dependent manner, and a decreased reduced glutathione (GSH) level and an increased malondialdehyde (MDA) content in 154 mg/kg group;and decreased serum levels of testosterone (T) and inhibin-B (INH-B) and an increased serum level of follicle stimulating hormone (FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone (LH) in 154 mg/kg group.
Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats.
- Atrazine /
- Reproductive toxicity /
- Oxidative stress /
- Endocrine disrupter

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Toxic Effects of Atrazine on Reproductive System of Male Rats

doi: 10.3967/bes2014.050

基金项目: National Natural Science Foundation of China(81030053)%National High-technology R esearch and Development Program (‘863’ program) of China(2010AA023001)

刊出日期: 2014-04-20

关键词:

Atrazine /

Reproductive toxicity /

Oxidative stress /

Endocrine disrupter

摘要: Objective This study was designed to evaluate the toxic effects of Atrazine (ATZ) on the reproductive system of male rats.
Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels.
Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group;a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups;decreased levels of acid phosphatase (ACP), alkaline phosphatase (AKP), lactic dehydrogenase (LDH), and succinate dehydrogenase (SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity (TAC) in a dose-dependent manner, and a decreased reduced glutathione (GSH) level and an increased malondialdehyde (MDA) content in 154 mg/kg group;and decreased serum levels of testosterone (T) and inhibin-B (INH-B) and an increased serum level of follicle stimulating hormone (FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone (LH) in 154 mg/kg group.
Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats.

English Abstract

Toxic Effects of Atrazine on Reproductive System of Male Rats

Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan, China

Funds: National Natural Science Foundation of China(81030053)%National High-technology R esearch and Development Program (‘863’ program) of China(2010AA023001)

Publish Date: 2014-04-20

Keywords:

Abstract: Objective This study was designed to evaluate the toxic effects of Atrazine (ATZ) on the reproductive system of male rats.
Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels.
Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group;a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups;decreased levels of acid phosphatase (ACP), alkaline phosphatase (AKP), lactic dehydrogenase (LDH), and succinate dehydrogenase (SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity (TAC) in a dose-dependent manner, and a decreased reduced glutathione (GSH) level and an increased malondialdehyde (MDA) content in 154 mg/kg group;and decreased serum levels of testosterone (T) and inhibin-B (INH-B) and an increased serum level of follicle stimulating hormone (FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone (LH) in 154 mg/kg group.
Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats.

Citation: