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INTRODUCTION
Cardiovascular disease (CVD) was ranked as the leading global cause of death in 1990 and 2010. The global death rate associated with CVD for individuals aged 15 to 49 was 10.7% in female patients and 12.8% in male patients in 2010[1]. In China, the number of all-age deaths from CVD was approximately 3.7 million in 2013, which increased by 46% from 1990[2]. Increased carotid artery intima-media thickness (CIMT) and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of CVD, and several studies have suggested that the predictive ability of carotid plaque for CVD is better than that of CIMT[3-8].
Metabolic syndrome (MetS) is characterized by a cluster of signs of metabolic disturbance, e.g., visceral obesity, dyslipidemia, hyperglycemia, and arterial hypertension[9]. The prevalence of MetS is about 27.0% in urban adults in Northeastern China[10], and MetS has reached epidemic proportions, even in adolescents[11]. Patients with MetS were more likely to have new plaques, carotid stenosis[12], and increased intima-media thickness (IMT)[13]. Association between MetS and IMT[14] was observed in various study populations[15-19], however, the findings were inconsistent [20,21]. In the current study, we explored the association between MetS and carotid atherosclerosis by measuring CIMT and carotid plaque.
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Of the 8,933 participants, 3,461 were found to have metabolic syndrome. Compared to participants without MetS, those with MetS were significantly older, had a lower education level and family income, and were more likely to consume alcohol. Waist circumference, uric acid, FPG, SBP, DBP, TG, LDL-C, and total cholesterol (TC) were significantly higher in participants with MetS than those without MetS, while HDL-C was significantly lower (P < 0.001) (Table 1).
Table 1. Characteristics of study population with and without metabolic syndrome
Characteristics Total With metabolic syndrome Without metabolic syndrome P-value N 8,933 3,461 5,472 Age (years) 54.21 ± 10.81 55.51 ± 10.03 53.38 ± 11.21 < 0.001 Male, n (%) 4,940 (55.30) 1,799 (57.40) 3,141 (51.98) < 0.001 Education, n (%) < 0.001 Illiteracy/primary school 907 (10.16) 394 (11.39) 513 (9.38) Middle school 5,631 (63.04) 2,243 (64.83) 3,388 (61.92) College or above 2,394 (26.80) 823 (23.79) 1,571 (28.71) Income, ¥/month, n (%) 0.001 < 3,000 6,449 (72.21) 2,535 (73.27) 3,914 (71.54) 3,001–5,000 2,070 (23.18) 801 (23.15) 1,269 (23.20) > 5,000 412 (4.61) 124 (3.58) 288 (5.26) Currently smoking, n (%) 2,063 (27.87) 799 (27.46) 1,264 (28.13) 0.527 Currently consuming alcohol, n (%) 1,821 (20.39) 759 (21.93) 1,062 (19.41) 0.039 Physical activity, n (%) 0.068 Inactive 3,144 (35.20) 1,175 (33.95) 1,969 (35.98) Moderately active 1,755 (19.65) 672 (19.42) 1,083(19.79) Very active 4,034 (45.16) 1,614 (46.63) 2,420 (44.23) Waist circumference (cm) 87.67 ± 9.83 93.68 ± 7.59 83.86 ± 9.17 < 0.001 Uric acid (µmol/L) 290.86 ± 87.39 312.20 ± 90.82 277.40 ± 82.37 < 0.001 FPG (mmol/L) 3.01 ± 2.22 3.46 ± 2.43 2.72 ± 2.02 < 0.001 SBP (mmHg) 131.11 ± 19.92 137.20 ± 19.43 127.25 ± 19.25 < 0.001 DBP (mmHg) 83.10 ± 12.00 86.37 ± 12.06 81.03 ± 11.48 < 0.001 TG (mmol/L) 1.69 ± 1.41 2.34 ± 1.77 1.27 ± 0.90 < 0.001 HDL-C (mmol/L) 1.47 ± 0.44 1.35 ± 0.41 1.54 ± 0.45 < 0.001 TC (mmol/L) 4.91 ± 0.98 5.23 ± 1.08 4.72 ± 0.86 < 0.001 LDL-C (mmol/L) 2.63 ± 0.71 2.82 ± 0.79 2.51 ± 0.62 < 0.001 Note. FPG, fasting plasma glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; TC, Total cholesterol; LDL-C, low-density lipoprotein cholesterol. Table 2 shows the distribution of MetS as well as its components in participants with and without carotid plaques. Participants with carotid plaques were more likely to have MetS. The single components of MetS were also different between participants with and without carotid plaques (P < 0.001), except for central obesity. The prevalence of carotid plaques was higher in participants with MetS (P < 0.001) and the average CIMT increased significantly from 0.766 mm in participants without MetS to 0.801 mm in participants with MetS (Figure 1).
Table 2. Metabolic syndrome (MetS) and its components in participants with and without carotid plaques
Items Total
N = 8,933Carotid plaques
n = 3,582No carotid plaques
n = 5,351P-value MetS, n (%) < 0.001 Yes 3,461 (38.74) 1,511 (42.18) 1,950 (36.44) No 5,472 (61.26) 2,071 (57.82) 3,401 (63.56) Single components of MetS, n (%) Central obesity 5,444 (60.94) 2,196 (61.31) 3,248 (60.70) 0.564 Raised TG 4,162 (46.59) 1,934 (53.99) 2,228 (41.64) < 0.001 Reduced HDL-C 5,086 (56.93) 2,102 (58.68) 2,984 (55.77) 0.006 Raised BP 5,394 (60.38) 2,633 (73.51) 2,761 (51.60) < 0.001 Raised FPG 1,667 (18.66) 758 (21.16) 909 (16.99) < 0.001 Num. of components of MetS, n (%) < 0.001 0 956 (10.70) 253 (7.06) 703 (13.14) 1 1,719 (19.24) 573 (16.00) 1,146 (21.42) 2 1,965 (22.00) 787 (21.97) 1,178 (22.01) 3 1,738 (19.46) 725 (20.24) 1,013 (18.93) 4 1,885 (21.10) 919 (25.66) 966 (18.05) 5 670 (7.50) 325 (9.07) 345 (6.45) Note. MetS, Metabolic syndrome; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; BP, blood pressure; FPG, fasting plasma glucose; Num., number. Figure 1. Prevalence of carotid plaques and average CIMT in participants with or without MetS. CIMT, intima-media thickness of common carotid artery; MetS, metabolic syndrome.
The odds ratio (OR) of carotid plaques for participants with MetS was 1.16 [95% confidence internal (CI): 1.03−1.30] after adjusting for possible confounding factors (Table 3). The adjusted ORs with 95% CIs of carotid plaques for participants with 1, 2, 3, 4 and 5 MetS components were 1.02 (0.81−1.28), 1.18 (0.95−1.48), 1.30 (1.03−1.63), 1.50 (1.19−1.88) and 1.45 (1.11−1.89), respectively, compared to participants without MetS components (P for trend < 0.001).
Table 3. Association between MetS and carotid plaque
Item Model 1 OR (95% CI) Model 2 OR (95% CI) Model 3 OR (95% CI) MetS 1.27 (1.17−1.39) 1.18 (1.07−1.30) 1.16 (1.03−1.30) Num. of components of MetS 0 1 1 1 1 1.39 (1.17−1.66) 1.04 (0.85−1.27) 1.02 (0.81−1.28) 2 1.86 (1.57−2.20) 1.28 (1.06−1.55) 1.18 (0.95−1.48) 3 1.99 (1.67−2.36) 1.41 (1.16 −1.71) 1.30 (1.03−1.63) 4 2.64 (2.23−3.13) 1.67 (1.38−2.03) 1.50 (1.19−1.88) 5 2.62 (2.12−3.23) 1.45 (1.15−1.83) 1.45 (1.11−1.89) P for trend < 0.001 < 0.001 < 0.001 Note. Model 1, crude OR; Model 2, adjusted for age and sex; Model 3, adjusted for Model 2 and education level, income, smoking, alcohol consumption, low-density lipoprotein cholesterol and uric acid. OR, odds ratio; CI, confidence internal; MetS, metabolic syndrome; Num., number. The average CIMT was greater by 0.020 mm (95% CI: 0.014−0.027) in participants with MetS than those without MetS (Table 4). In participants with multiple MetS components, CIMT increased by 0.023 mm, 0.022 mm, 0.042 mm, and 0.035 mm for 2, 3, 4, and 5 MetS components, respectively.
Table 4. Association between MetS and average CIMT
Item Model 1 Model 2 Model 3 β (95% CI) P β (95% CI) P β (95% CI) P MetS 0.035 (0.028−0.042) < 0.0001 0.023 (0.017−0.029) < 0.0001 0.020 (0.014−0.027) < 0.001 Num. of components of MetS 0 0 0 0 1 0.035 (0.022−0.047) < 0.0001 0.007 (−0.003−0.017) 0.192 0.010 (−0.001−0.022) 0.069 2 0.064 (0.052−0.076) < 0.0001 0.021 (0.012−0.032) < 0.0001 0.023 (0.011−0.033) < 0.001 3 0.063 (0.050−0.075) < 0.0001 0.021 (0.011−0.031) < 0.0001 0.022 (0.010−0.033) < 0.001 4 0.098 (0.086−0.110) < 0.0001 0.042 (0.032−0.052) < 0.0001 0.042 (0.030−0.054) < 0.001 5 0.104 (0.089−0.120) < 0.001 0.038 (0.025−0.051) < 0.001 0.035 (0.020−0.049) < 0.001 Note. Model 1, crude OR; Model 2, adjusted for age and sex; Model 3, adjusted for Model 2 and education level, income, smoking, alcohol consumption, low-density lipoprotein cholesterol and uric acid. MetS, metabolic syndrome; CIMT, carotid artery intima-media thickness; CI, confidence internal; Num, number.
doi: 10.3967/bes2019.114
Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China
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Abstract:
Objective Increased carotid artery intima-media thickness (CIMT) and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease (CVD). The components of metabolic syndrome (MetS) are linked to CVD, but the association between MetS and CVD is controversial. Methods A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities. MetS was defined by the International Diabetes Federation criteria. CIMT and carotid plaque were measured using color Doppler ultrasound. Logistic regression models were used to assess the association of MetS with carotid plaque and CIMT. Results MetS was found among 3,461 (3,461/8,933) participants. The odds ratio and 95% confidence internal (CI) for carotid plaques in participants with MetS was 1.16 (1.03−1.30). The risk of carotid plaques increased with the number of MetS components. The average CIMT was higher in participants with MetS (β = 0.020, 95% CI, 0.014−0.027) and in participants with more MetS components. Conclusion Individuals with MetS are at an increased risk for carotid atherosclerosis compared to those without MetS. -
Key words:
- Metabolic syndrome /
- Components /
- Carotid atherosclerosis /
- Intima-media thickness
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Table 1. Characteristics of study population with and without metabolic syndrome
Characteristics Total With metabolic syndrome Without metabolic syndrome P-value N 8,933 3,461 5,472 Age (years) 54.21 ± 10.81 55.51 ± 10.03 53.38 ± 11.21 < 0.001 Male, n (%) 4,940 (55.30) 1,799 (57.40) 3,141 (51.98) < 0.001 Education, n (%) < 0.001 Illiteracy/primary school 907 (10.16) 394 (11.39) 513 (9.38) Middle school 5,631 (63.04) 2,243 (64.83) 3,388 (61.92) College or above 2,394 (26.80) 823 (23.79) 1,571 (28.71) Income, ¥/month, n (%) 0.001 < 3,000 6,449 (72.21) 2,535 (73.27) 3,914 (71.54) 3,001–5,000 2,070 (23.18) 801 (23.15) 1,269 (23.20) > 5,000 412 (4.61) 124 (3.58) 288 (5.26) Currently smoking, n (%) 2,063 (27.87) 799 (27.46) 1,264 (28.13) 0.527 Currently consuming alcohol, n (%) 1,821 (20.39) 759 (21.93) 1,062 (19.41) 0.039 Physical activity, n (%) 0.068 Inactive 3,144 (35.20) 1,175 (33.95) 1,969 (35.98) Moderately active 1,755 (19.65) 672 (19.42) 1,083(19.79) Very active 4,034 (45.16) 1,614 (46.63) 2,420 (44.23) Waist circumference (cm) 87.67 ± 9.83 93.68 ± 7.59 83.86 ± 9.17 < 0.001 Uric acid (µmol/L) 290.86 ± 87.39 312.20 ± 90.82 277.40 ± 82.37 < 0.001 FPG (mmol/L) 3.01 ± 2.22 3.46 ± 2.43 2.72 ± 2.02 < 0.001 SBP (mmHg) 131.11 ± 19.92 137.20 ± 19.43 127.25 ± 19.25 < 0.001 DBP (mmHg) 83.10 ± 12.00 86.37 ± 12.06 81.03 ± 11.48 < 0.001 TG (mmol/L) 1.69 ± 1.41 2.34 ± 1.77 1.27 ± 0.90 < 0.001 HDL-C (mmol/L) 1.47 ± 0.44 1.35 ± 0.41 1.54 ± 0.45 < 0.001 TC (mmol/L) 4.91 ± 0.98 5.23 ± 1.08 4.72 ± 0.86 < 0.001 LDL-C (mmol/L) 2.63 ± 0.71 2.82 ± 0.79 2.51 ± 0.62 < 0.001 Note. FPG, fasting plasma glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; TC, Total cholesterol; LDL-C, low-density lipoprotein cholesterol. Table 2. Metabolic syndrome (MetS) and its components in participants with and without carotid plaques
Items Total
N = 8,933Carotid plaques
n = 3,582No carotid plaques
n = 5,351P-value MetS, n (%) < 0.001 Yes 3,461 (38.74) 1,511 (42.18) 1,950 (36.44) No 5,472 (61.26) 2,071 (57.82) 3,401 (63.56) Single components of MetS, n (%) Central obesity 5,444 (60.94) 2,196 (61.31) 3,248 (60.70) 0.564 Raised TG 4,162 (46.59) 1,934 (53.99) 2,228 (41.64) < 0.001 Reduced HDL-C 5,086 (56.93) 2,102 (58.68) 2,984 (55.77) 0.006 Raised BP 5,394 (60.38) 2,633 (73.51) 2,761 (51.60) < 0.001 Raised FPG 1,667 (18.66) 758 (21.16) 909 (16.99) < 0.001 Num. of components of MetS, n (%) < 0.001 0 956 (10.70) 253 (7.06) 703 (13.14) 1 1,719 (19.24) 573 (16.00) 1,146 (21.42) 2 1,965 (22.00) 787 (21.97) 1,178 (22.01) 3 1,738 (19.46) 725 (20.24) 1,013 (18.93) 4 1,885 (21.10) 919 (25.66) 966 (18.05) 5 670 (7.50) 325 (9.07) 345 (6.45) Note. MetS, Metabolic syndrome; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; BP, blood pressure; FPG, fasting plasma glucose; Num., number. Table 3. Association between MetS and carotid plaque
Item Model 1 OR (95% CI) Model 2 OR (95% CI) Model 3 OR (95% CI) MetS 1.27 (1.17−1.39) 1.18 (1.07−1.30) 1.16 (1.03−1.30) Num. of components of MetS 0 1 1 1 1 1.39 (1.17−1.66) 1.04 (0.85−1.27) 1.02 (0.81−1.28) 2 1.86 (1.57−2.20) 1.28 (1.06−1.55) 1.18 (0.95−1.48) 3 1.99 (1.67−2.36) 1.41 (1.16 −1.71) 1.30 (1.03−1.63) 4 2.64 (2.23−3.13) 1.67 (1.38−2.03) 1.50 (1.19−1.88) 5 2.62 (2.12−3.23) 1.45 (1.15−1.83) 1.45 (1.11−1.89) P for trend < 0.001 < 0.001 < 0.001 Note. Model 1, crude OR; Model 2, adjusted for age and sex; Model 3, adjusted for Model 2 and education level, income, smoking, alcohol consumption, low-density lipoprotein cholesterol and uric acid. OR, odds ratio; CI, confidence internal; MetS, metabolic syndrome; Num., number. Table 4. Association between MetS and average CIMT
Item Model 1 Model 2 Model 3 β (95% CI) P β (95% CI) P β (95% CI) P MetS 0.035 (0.028−0.042) < 0.0001 0.023 (0.017−0.029) < 0.0001 0.020 (0.014−0.027) < 0.001 Num. of components of MetS 0 0 0 0 1 0.035 (0.022−0.047) < 0.0001 0.007 (−0.003−0.017) 0.192 0.010 (−0.001−0.022) 0.069 2 0.064 (0.052−0.076) < 0.0001 0.021 (0.012−0.032) < 0.0001 0.023 (0.011−0.033) < 0.001 3 0.063 (0.050−0.075) < 0.0001 0.021 (0.011−0.031) < 0.0001 0.022 (0.010−0.033) < 0.001 4 0.098 (0.086−0.110) < 0.0001 0.042 (0.032−0.052) < 0.0001 0.042 (0.030−0.054) < 0.001 5 0.104 (0.089−0.120) < 0.001 0.038 (0.025−0.051) < 0.001 0.035 (0.020−0.049) < 0.001 Note. Model 1, crude OR; Model 2, adjusted for age and sex; Model 3, adjusted for Model 2 and education level, income, smoking, alcohol consumption, low-density lipoprotein cholesterol and uric acid. MetS, metabolic syndrome; CIMT, carotid artery intima-media thickness; CI, confidence internal; Num, number. -
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