ZHANG Ming Liang; HOU Xu Hong; ZHU Yun Xia; LU Jun Xi; PENG Liang Pu; GU Hui Lin; JIA Wei Ping

doi:10.3967/0895-3988.2012.01.006

doi: 10.3967/0895-3988.2012.01.006

基金项目: This research was supported by the Major Program of Shanghai Municipality for Basic Research(08dj1400601)%Shanghai Key Laboratory of Diabetes Mellitus(08DZ2230200)%by the Key Project of Science and Technology of Shanghai(09DZ1950202)

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes; Shanghai Key Laboratory of Diabetes Mellitus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Shanghai Caoyang Community Health Care Center, Shanghai 200062, China
Shanghai Huayang Community Health Care Center, Shanghai 200042, China

Funds: This research was supported by the Major Program of Shanghai Municipality for Basic Research(08dj1400601)%Shanghai Key Laboratory of Diabetes Mellitus(08DZ2230200)%by the Key Project of Science and Technology of Shanghai(09DZ1950202)

摘要: Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6％ vs.21.3％) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P＜0.01) and to elevated blood glucose in the elderly group (HR=1.39,P＜0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.
- /
- /
- /
Abstract: Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6％ vs.21.3％) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P＜0.01) and to elevated blood glucose in the elderly group (HR=1.39,P＜0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.
- Metabolic syndrome /
- Cardiovascular disease /
- The middle-aged /
- The elderly

[1]	HONG Le, YAN Miao Miao, ZHANG Yun Quan, WANG Kai, WANG Ya Qi, LUO Si Qi, WANG Fang. Global Burden of Cardiovascular Disease Attributable to High Temperature in 204 Countries and Territories from 1990 to 2019 . Biomedical and Environmental Sciences, 2023, 36(3): 222-230. doi: 10.3967/bes2023.025
[2]	The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary . Biomedical and Environmental Sciences, 2023, 36(8): 669-701. doi: 10.3967/bes2023.106
[3]	The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary . Biomedical and Environmental Sciences, 2022, 35(7): 573-603. doi: 10.3967/bes2022.079
[4]	BAI Jing, WANG Yun, ZHANG Xian Fan, OUYANG Yi Fei, ZHANG Bing, WANG Zhi Hong, DU Shu Fa, WANG Hui Jun. Associations of Sedentary Time and Physical Activity with Metabolic Syndrome among Chinese Adults: Results from the China Health and Nutrition Survey . Biomedical and Environmental Sciences, 2021, 34(12): 963-975. doi: 10.3967/bes2021.132
[5]	LI Ya Mei, ZOU Zhi Yong, MA Ying Hua, LUO Jia You, JING Jin, ZHANG Xin, LUO Chun Yan, WANG Hong, ZHAO Hai Ping, PAN De Hong, LUO Mi Yang. Predicting Metabolic Syndrome Using Anthropometric Indices among Chinese Adolescents with Different Nutritional Status: A Multicenter Cross-sectional Study . Biomedical and Environmental Sciences, 2021, 34(9): 673-682. doi: 10.3967/bes2021.095
[6]	YAO Yan, LIU Hua Min, WANG Xian Wei, FENG Xia, GAO Li Jian, LI Dong, ZHOU Yong. Effect of Body Mass Index on the Associations between Parity and Metabolic Syndrome and its Components among Northern Chinese Women . Biomedical and Environmental Sciences, 2020, 33(1): 11-18. doi: 10.3967/bes2020.002
[7]	ZHOU Ping An, ZHANG Chen Huan, CHEN Yan Ru, LI Dong, SONG Dai Yu, LIU Hua Min, ZHOU Ming Yue, SONG Guo Shun, CHEN Sheng Yun. Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China . Biomedical and Environmental Sciences, 2019, 32(12): 914-921. doi: 10.3967/bes2019.114
[8]	WU Xue Yan, LIN Lin, Qi Hong Yan, DU Rui, HU Chun Yan, MA Li Na, PENG Kui, LI Mian, XU Yu, XU Min, CHEN Yu Hong, LU Jie Li, BI Yu Fang, WANG Wei Qing, NING Guang. Association between Lipoprotein (a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort . Biomedical and Environmental Sciences, 2019, 32(7): 477-485. doi: 10.3967/bes2019.065
[9]	CHENG Di, DU Rui, WU Xue Yan, LIN Lin, PENG Kui, MA Li Na, XU Yu, XU Min, CHEN Yu Hong, BI Yu Fang, WANG Wei Qing, DAI Meng, LU Jie Li. Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes . Biomedical and Environmental Sciences, 2018, 31(2): 106-114. doi: 10.3967/bes2018.013
[10]	WANG YunFeng, TANG Zhe, GUO Jin, TAO LiXin, LIU Long, LI HaiBin, LI DiTian, GUO XiuHua, YANG XingHua. BMI and BMI Changes to All-cause Mortality among the Elderly in Beijing: a 20-year Cohort Study . Biomedical and Environmental Sciences, 2017, 30(2): 79-87. doi: 10.3967/bes2017.011
[11]	ZHOU Jun Mei, ZHANG Ming, WANG Shu, WANG Bing Yuan, HAN Cheng Yi, REN Yong Cheng, ZHANG Lu, ZHANG Hong Yan, YANG Xiang Yu, ZHAO Yang, HU Dong Sheng. Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population：A Meta-analysis . Biomedical and Environmental Sciences, 2016, 29(7): 505-515. doi: 10.3967/bes2016.066
[12]	LI Jian Hong, WANG Li Min, LI Yi Chong, ZHANG Mei, WANG Lin Hong. Prevalence of Major Cardiovascular Risk Factors and Cardiovascular Disease in Women in China:Surveillance Efforts . Biomedical and Environmental Sciences, 2016, 29(3): 205-211. doi: 10.3967/bes2016.025
[13]	FAN Jie, LI Guo Qi, LIU Jing, WANG Wei, WANG Miao, QI Yue, XIE Wu Xiang, LIU Jun, ZHAO Fan, LI Yan, ZHAO Dong. Impact of Cardiovascular Disease Deaths on Life Expectancy in Chinese Population . Biomedical and Environmental Sciences, 2014, 27(3): 162-168. doi: 10.3967/bes2014.037
[14]	YIN Xue Yao, ZHENG Fen Ping, ZHOU Jia Qiang, DU Ying, PAN Qian Qian, ZHANG Sai Fei, YU Dan, LI Hong. Central Obesity and Metabolic Risk Factors in Middle-aged Chinese . Biomedical and Environmental Sciences, 2014, 27(5): 343-352. doi: 10.3967/bes2014.059
[15]	HOU Xin Guo, WANG Chuan, MA Ze Qiang, YANG Wei Fang, WANG Ji Xiang, LI Cheng Qiao, WANG Yu Lian, LIU Shu Min, Hu Xiu Ping, ZHANG Xiu Ping, JIANG Mei, WANG Wei Qing, NING Guang, ZHENG Hui Zhen, MA Ai Xia, SUN Yu, SONG Jun, LIN Peng, LIANG Kai, LIU Fu Qiang, LI Wen Juan, XIAO Juan, GONG Lei, WANG Mei Jian, LIU Ji Dong, YAN Fei, YANG Jun Peng, WANG Ling Shu, TIAN Meng, ZHAO Ru Xing, JIANG Ling, CHEN Li. Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China . Biomedical and Environmental Sciences, 2014, 27(5): 353-359. doi: 10.3967/bes2014.060
[16]	PENG Hao, HAN Shu Hai, LIU Hai Ying, Vasisht CHANDNI, CAI Xiao Qing, ZHANG Yong Hong. Relationship of Inflammation and Endothelial Dysfunction with Risks to Cardiovascular Disease among People in Inner Mongolia of China . Biomedical and Environmental Sciences, 2013, 26(10): 792-800. doi: 10.3967/bes2013.002
[17]	JIA Wei Ping. The Impact of Cigarette Smoking on Metabolic Syndrome . Biomedical and Environmental Sciences, 2013, 26(12): 947-951. doi: 10.3967/bes2013.029
[18]	YUAN YuanZhi, M. Kamran IKRAM, JIANG SunFang, LIN HuanDong, REN LiMin, YAN HongMei, SHENG JianHua, CHEN XuSheng, GAO Xin. Hyperuricemia Accompanied with Changes in the Retinal Microcirculation in a Chinese High-risk Population for Diabetes . Biomedical and Environmental Sciences, 2011, 24(2): 146-154. doi: 10.3967/0895-3988.2011.02.009
[19]	WEI-PING JIA, CHEN WANG, SHAN JIANG, JIE-MIN PAN. Characteristics of Obesity and Its Related Disorders in China . Biomedical and Environmental Sciences, 2010, 23(1): 4-11.
[20]	LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese . Biomedical and Environmental Sciences, 2008, 21(3): 188-192.

点击查看大图

计量

文章访问数: 1438
HTML全文浏览量: 339
PDF下载量: 44
被引次数: 0

doi: 10.3967/0895-3988.2012.01.006

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

计量

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

doi: 10.3967/0895-3988.2012.01.006

English Abstract

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

全文HTML

目录

doi: 10.3967/0895-3988.2012.01.006

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

计量

出版历程

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

doi: 10.3967/0895-3988.2012.01.006

English Abstract

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

全文HTML

目录