CHEN Yan Qin; XU Qiong Ming; LIU Yan Li; LI Xiao Ran; YANG Shi Lin; ZHUGE Hong Xiang

doi:10.3967/0895-3988.2012.02.015

Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis

CHEN Yan Qin, XU Qiong Ming, LIU Yan Li, LI Xiao Ran, YANG Shi Lin, ZHUGE Hong Xiang

文章导航 > Biomedical and Environmental Sciences > 2012 > 25(2): 224-229

CHEN Yan Qin, XU Qiong Ming, LIU Yan Li, LI Xiao Ran, YANG Shi Lin, ZHUGE Hong Xiang. Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis[J]. Biomedical and Environmental Sciences, 2012, 25(2): 224-229. doi: 10.3967/0895-3988.2012.02.015

Citation:

CHEN Yan Qin, XU Qiong Ming, LIU Yan Li, LI Xiao Ran, YANG Shi Lin, ZHUGE Hong Xiang. Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis[J]. Biomedical and Environmental Sciences, 2012, 25(2): 224-229. doi: 10.3967/0895-3988.2012.02.015

doi: 10.3967/0895-3988.2012.02.015

基金项目: the Natural Science Fund of Jiangsu Province(BK2009076)

Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis

Department of Parasitology, Medical College of Soochow University, Suzhou 215123, Jiangsu, China;;Medical College of Nanyang, Nanyang 473000, Henan, China
College of Pharmacy, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
Department of Parasitology, Medical College of Soochow University, Suzhou 215123, Jiangsu, China

Funds: the Natural Science Fund of Jiangsu Province(BK2009076)

摘要: Objective To observe the toxicity of Pulsatilla chinensis (Bunge) Regel saponins (PRS) against Oncomelania hupensis (0.hupensis).Methods O.hupensis snails were exposed to 40％ and 80％ of 24 h LC50 of PRS for 24 h,and then choline esterase (CHE),alanine aminotransferase (ALT),alkaline phosphatase (ALP),lactate dehydrogenase (LDH) activities in cephalopodium and liver of snails were determined.Niclosamide (NIC) was used as the reference molluscicide.Zebra fish lethality test was evaluated to non-target aquatic species of PRS.Results The molluscicidal activity of PRS (LC50 at 24 h:0.48 mg/L) was similar to that of NIC (LC50 at 24 h:0.16 mg/L).Significant alterations about CHE,ALP,and ALT activities both in the cephalopodium and the liver of snails were observed when O.hupensis was exposed to 40％ and 80％ LC50 of PRS or NIC for 24 h.PRS and NIC could not affect LDH activity in the cephalopodium and the liver.Lower toxicity to fish of PRS was observed up to the highest concentration tested than NIC.Conclusion PRS,as compared with the reference molluscicide NIC,is thought to be used for the control of harmful vector snails safely.
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Abstract: Objective To observe the toxicity of Pulsatilla chinensis (Bunge) Regel saponins (PRS) against Oncomelania hupensis (0.hupensis).Methods O.hupensis snails were exposed to 40％ and 80％ of 24 h LC50 of PRS for 24 h,and then choline esterase (CHE),alanine aminotransferase (ALT),alkaline phosphatase (ALP),lactate dehydrogenase (LDH) activities in cephalopodium and liver of snails were determined.Niclosamide (NIC) was used as the reference molluscicide.Zebra fish lethality test was evaluated to non-target aquatic species of PRS.Results The molluscicidal activity of PRS (LC50 at 24 h:0.48 mg/L) was similar to that of NIC (LC50 at 24 h:0.16 mg/L).Significant alterations about CHE,ALP,and ALT activities both in the cephalopodium and the liver of snails were observed when O.hupensis was exposed to 40％ and 80％ LC50 of PRS or NIC for 24 h.PRS and NIC could not affect LDH activity in the cephalopodium and the liver.Lower toxicity to fish of PRS was observed up to the highest concentration tested than NIC.Conclusion PRS,as compared with the reference molluscicide NIC,is thought to be used for the control of harmful vector snails safely.
- Oncomelania hupensis /
- Molluscicidal activity /
- Saponin /
- Pulsatilla chinensis (Bunge) Regel /
- Niclosamide

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Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis

doi: 10.3967/0895-3988.2012.02.015

基金项目: the Natural Science Fund of Jiangsu Province(BK2009076)

刊出日期: 2012-04-20

关键词:

Oncomelania hupensis /

Molluscicidal activity /

Saponin /

Pulsatilla chinensis (Bunge) Regel /

Niclosamide

摘要: Objective To observe the toxicity of Pulsatilla chinensis (Bunge) Regel saponins (PRS) against Oncomelania hupensis (0.hupensis).Methods O.hupensis snails were exposed to 40％ and 80％ of 24 h LC50 of PRS for 24 h,and then choline esterase (CHE),alanine aminotransferase (ALT),alkaline phosphatase (ALP),lactate dehydrogenase (LDH) activities in cephalopodium and liver of snails were determined.Niclosamide (NIC) was used as the reference molluscicide.Zebra fish lethality test was evaluated to non-target aquatic species of PRS.Results The molluscicidal activity of PRS (LC50 at 24 h:0.48 mg/L) was similar to that of NIC (LC50 at 24 h:0.16 mg/L).Significant alterations about CHE,ALP,and ALT activities both in the cephalopodium and the liver of snails were observed when O.hupensis was exposed to 40％ and 80％ LC50 of PRS or NIC for 24 h.PRS and NIC could not affect LDH activity in the cephalopodium and the liver.Lower toxicity to fish of PRS was observed up to the highest concentration tested than NIC.Conclusion PRS,as compared with the reference molluscicide NIC,is thought to be used for the control of harmful vector snails safely.

English Abstract

Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis

Department of Parasitology, Medical College of Soochow University, Suzhou 215123, Jiangsu, China;;Medical College of Nanyang, Nanyang 473000, Henan, China

College of Pharmacy, Medical College of Soochow University, Suzhou 215123, Jiangsu, China

Department of Parasitology, Medical College of Soochow University, Suzhou 215123, Jiangsu, China

Funds: the Natural Science Fund of Jiangsu Province(BK2009076)

Publish Date: 2012-04-20

Keywords:

Abstract: Objective To observe the toxicity of Pulsatilla chinensis (Bunge) Regel saponins (PRS) against Oncomelania hupensis (0.hupensis).Methods O.hupensis snails were exposed to 40％ and 80％ of 24 h LC50 of PRS for 24 h,and then choline esterase (CHE),alanine aminotransferase (ALT),alkaline phosphatase (ALP),lactate dehydrogenase (LDH) activities in cephalopodium and liver of snails were determined.Niclosamide (NIC) was used as the reference molluscicide.Zebra fish lethality test was evaluated to non-target aquatic species of PRS.Results The molluscicidal activity of PRS (LC50 at 24 h:0.48 mg/L) was similar to that of NIC (LC50 at 24 h:0.16 mg/L).Significant alterations about CHE,ALP,and ALT activities both in the cephalopodium and the liver of snails were observed when O.hupensis was exposed to 40％ and 80％ LC50 of PRS or NIC for 24 h.PRS and NIC could not affect LDH activity in the cephalopodium and the liver.Lower toxicity to fish of PRS was observed up to the highest concentration tested than NIC.Conclusion PRS,as compared with the reference molluscicide NIC,is thought to be used for the control of harmful vector snails safely.

Citation:

CHEN Yan Qin, XU Qiong Ming, LIU Yan Li, LI Xiao Ran, YANG Shi Lin, ZHUGE Hong Xiang. Laboratory Evaluation of the Molluscicidal Activity of Pulsatilla Chinensis (Bunge) Regel Saponins against the Snail Oncomelania Hupensis[J]. Biomedical and Environmental Sciences, 2012, 25(2): 224-229. doi: 10.3967/0895-3988.2012.02.015