YOU Hai Fei; ZHAO Jing Zhi; ZHAI Yu Jia; YIN Lei; PANG Chao; LUO Xin Ping; ZHANG Ming; WANG Jin Jin; LI Lin Lin; WANG Yan; WANG Qian; WANG Bing Yuan; REN Yong Cheng; HU Dong Sheng

doi:10.3967/bes2015.073

doi: 10.3967/bes2015.073

基金项目: This study was supported by the National Natural Science Foundation of China(81072359)%Natural Science Foundation of Guangdong Province(S2013010016791)%Science and Technology Development Foundation of Shenzhen(JCYJ20120613112221107 and JCYJ20130326110246234)%Natural Science Foundation of Shenzhen University(801-00035911)

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi’an 710023, Shannxi, China
Military Hospital of Henan Province, Zhengzhou 450003, Henan, China
Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China
Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China

Funds: This study was supported by the National Natural Science Foundation of China(81072359)%Natural Science Foundation of Guangdong Province(S2013010016791)%Science and Technology Development Foundation of Shenzhen(JCYJ20120613112221107 and JCYJ20130326110246234)%Natural Science Foundation of Shenzhen University(801-00035911)

摘要: Objective To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
Methods A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95%confidence intervals (95%CIs) were calculated to describe the strength of the association by logistic regression.
Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
- /
- /
- /
- /
Abstract: Objective To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
Methods A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95%confidence intervals (95%CIs) were calculated to describe the strength of the association by logistic regression.
Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
- Low-density lipoprotein receptor-related protein 5 /
- Gene polymorphism /
- Type 2 diabetes mellitus /
- Haplotype /
- Metabolic characteristics

[1]	Xiaoyun Shan, Yuting Li, Xiayu Zhao, Yichun Hu, Siran Li, Huidi Zhang, Yang Cao, Rui Wang, Lichen Yang. Threshold-Effect Associations of Serum 25-hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age . Biomedical and Environmental Sciences, 2024, 37(): 1-14. doi: 10.3967/bes2024.151
[2]	Zhang Mengqing, Lin Chu, Cai Xiaoling, Jiao Ruoyang, Bai Shuzhen, Li Zonglin, Hu Suiyuan, Lyu Fang, Yang Wenjia, Ji Linong. The Association between GLP-1 Receptor-Based Agonists and the Incidence of Asthma in Patients with Type 2 Diabetes and/or Obesity: A Meta-Analysis . Biomedical and Environmental Sciences, 2024, 37(6): 607-616. doi: 10.3967/bes2024.067
[3]	Rajendran Jayanthi, Anandaraj Lokeshmaran, Ramasamy Sathiya, Abu Raghavan Srinivasan. Evaluation of Insulin Resistance Markers and Their Relationship with ADIPO Q Gene Polymorphism in Clinically Euthyroid Type 2 Diabetic Patients . Biomedical and Environmental Sciences, 2022, 35(6): 543-546. doi: 10.3967/bes2022.072
[4]	CHEN Yan Mei, XU Ping, WANG Zhou Tian, ZHU Yu Mei, GONG Chun Mei, HUANG Chang Hua, LIU Xiao Li, ZHOU Ji Chang. Polymorphisms of the Vitamin D Receptor Gene and Sex-Differential Associations with Lipid Profiles in Chinese Han Adults . Biomedical and Environmental Sciences, 2022, 35(2): 115-125. doi: 10.3967/bes2022.016
[5]	HAN Han, ZHAO Ming Xu, WANG Yan, WANG Jun, REN Bing Nan, GE Hui Na, WANG Teng, SUN Bei Bei, BA Yue, LI Wen Jie. Significant Polymorphisms of Vitamin D Receptor Gene (rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area . Biomedical and Environmental Sciences, 2019, 32(1): 58-62. doi: 10.3967/bes2019.009
[6]	ZHANG Qun, LIU Di, ZHAO ZhongYao, SUN Qi, DING LiXiang, WANG YouXin. Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis . Biomedical and Environmental Sciences, 2017, 30(4): 288-295. doi: 10.3967/bes2017.038
[7]	MIAO Dan Dan, PAN En Chun, ZHANG Qin, SUN Zhong Ming, QIN Yu, WU Ming. Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People . Biomedical and Environmental Sciences, 2017, 30(2): 106-112. doi: 10.3967/bes2017.014
[8]	TAO Yong Kang, YU Pu Lin, BAI Yong Ping, YAN Sheng Tao, ZHAO Shui Ping, ZHANG Guo Qiang. Role of PERK/eIF2α/CHOP Endoplasmic Reticulum Stress Pathway in Oxidized Low-density Lipoprotein Mediated Induction of Endothelial Apoptosis . Biomedical and Environmental Sciences, 2016, 29(12): 868-876. doi: 10.3967/bes2016.116
[9]	YAN-LI YANG, RUO-LAN XIANG, CHANG YANG, XIAO-JUN LIU, WEN-JUN SHEN, JIN ZUO, YONG-SHENG CHANG, FU-DE FANG. Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus . Biomedical and Environmental Sciences, 2009, 22(5): 359-368.
[10]	MIN YANG, CHANG-CHUN QIU, WEI CHEN, LING-LING XU, MIAO YU, HONG-DING XIANG. Identification of a Regulatory Single Nucleotide Polymorphism in the Adiponectin (APM1) Gene Associated with Type2 Diabetes in Han Nationality . Biomedical and Environmental Sciences, 2008, 21(6): 454-459.
[11]	LEI HUANG, XIAO-MING SONG, WEN-LI ZHU, YONG LI. Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects . Biomedical and Environmental Sciences, 2008, 21(6): 514-520.
[12]	SHAN-FA YU, WEN-HUI ZHOU, KAI-YOU JIANG, GUI-ZHENG GU, SHENG WANG. Job Stress, Gene Polymorphism of β2-AR, and Prevalence of Hypertension . Biomedical and Environmental Sciences, 2008, 21(3): 239-246.
[13]	CONG-RONG WANG, CHENG HU, RONG ZHANG, QI-CHEN FANG, XIAO-JING MA, WEI-PING JIA, KUN-SAN XIANG. Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population . Biomedical and Environmental Sciences, 2007, 20(1): 41-46.
[14]	XIAO-CHAO CHEN, MING-TONG XU, WU ZHOU, CHUN-LI HAN, WEI-QING CHEN. A Meta-analysis of β-fibrinogen Gene-455G/A Polymorphism and Plasma Fibrinogen Level in Chinese Cerebral Infarction Patients . Biomedical and Environmental Sciences, 2007, 20(5): 366-372.
[15]	MIN YANG, CHANG-CHUN QIU, QUN XU, HONG-DING XIANG. Association of Angiotensin Converting Enzyme Gene I/D Polymorphism With Type 2 Diabetes Mellitus . Biomedical and Environmental Sciences, 2006, 19(4): 323-327.
[16]	XIAO-MING SONG, XIAO-YING ZHENG, WEN-LI ZHU, LEI HUANG, YONG LI. Relationship Between Polymorphism of Cystathionine beta Synthase Gene and Congenital Heart Disease in Chinese Nuclear Families . Biomedical and Environmental Sciences, 2006, 19(6): 452-456.
[17]	HONG-QUAN LI, ZHUO LI, YING LIU, JUN-HONG LI, JIAN-QUN DONG, JI-RONG GAO, CHUN-YAN GOU, HUI LI. Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection . Biomedical and Environmental Sciences, 2006, 19(2): 133-136.
[18]	JUN CHENG, WEN-LI ZHU, JING-JING DAO, SHU-QING LI, YONG LI. Relationship Between Polymorphism of Methylenetetrahydrofolate Dehydrogenase and Congenital Heart Defect . Biomedical and Environmental Sciences, 2005, 18(1): 58-64.
[19]	WEN-LI ZHU, JUN CHENG, JING-JING DAO, RU-BING ZHAO, LI-YING YAN, SHU-QING LI, YONG LI. Polymorphism of Methionine Synthase Gene in Nuclear Families of Congenital Heart Disease . Biomedical and Environmental Sciences, 2004, 17(1): 57-64.
[20]	SUN Hong-xia, ZHANG KUI-XING, DU WEI-NAN, SHI JIN-XIU, JIANG ZHENG-WEN, SUN HAO, ZUO JIN, HUANG WEI, CHEN ZHU, SHEN YAN, YAO Zhi-Jian, QIANG Bo-Qin, FANG FU-DE. Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China . Biomedical and Environmental Sciences, 2002, 15(1): 75-82.

点击查看大图

计量

文章访问数: 1276
HTML全文浏览量: 320
PDF下载量: 78
被引次数: 0

doi: 10.3967/bes2015.073

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

计量

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

doi: 10.3967/bes2015.073

English Abstract

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

全文HTML

目录

doi: 10.3967/bes2015.073

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

计量

出版历程

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

doi: 10.3967/bes2015.073

English Abstract

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study

全文HTML

目录