Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study

SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan

SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052
Citation: SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052

doi: 10.3967/bes2016.052
基金项目: This study was supported by Shanghai Municipal health Bureau(number 20134332)%the research grants of the Shanghai Municipal Bureau of Health(number 20134053)%Health Fields Specific Research Grant(201202012)%the Major Project of Shanghai Municipal Science and Technology Commission(11DJ1400202)%the four grants from Key Discipline of Shanghai Public Health-Food and Nutrition Sciences(12GWZX0702)%Shanghai Rising-Star Program(15YF1411100)

Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study

Funds: This study was supported by Shanghai Municipal health Bureau(number 20134332)%the research grants of the Shanghai Municipal Bureau of Health(number 20134053)%Health Fields Specific Research Grant(201202012)%the Major Project of Shanghai Municipal Science and Technology Commission(11DJ1400202)%the four grants from Key Discipline of Shanghai Public Health-Food and Nutrition Sciences(12GWZX0702)%Shanghai Rising-Star Program(15YF1411100)
计量
  • 文章访问数:  1519
  • HTML全文浏览量:  521
  • PDF下载量:  135
  • 被引次数: 0
出版历程
  • 刊出日期:  2016-06-20

Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study

doi: 10.3967/bes2016.052
    基金项目:  This study was supported by Shanghai Municipal health Bureau(number 20134332)%the research grants of the Shanghai Municipal Bureau of Health(number 20134053)%Health Fields Specific Research Grant(201202012)%the Major Project of Shanghai Municipal Science and Technology Commission(11DJ1400202)%the four grants from Key Discipline of Shanghai Public Health-Food and Nutrition Sciences(12GWZX0702)%Shanghai Rising-Star Program(15YF1411100)

摘要: Objective This study was designed to evaluate the prevalence of thyroid nodules (TNs) and its relationship with urine iodine concentrations (UICs) after the regional rapid economic growth and lifestyle changes.
Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine (T3), tetraiodothyronine (T4), serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and TSH receptor antibody (TRAb) levels were measured for each individual subject.
Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs (P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs (P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L.
Conclusion The prevalence of TNs was nearly 30%and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and>400 μg/L. Very low or high UIC levels need attention and correction.

English Abstract

SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052
Citation: SONG Jun, ZOU Shu Rong, GUO Chang Yi, ZANG Jia Jie, ZHU Zhen Ni, MI Ming, HUANG Cui Hua, YU Hui Ting, LU Xi, RUAN Ye, WU Fan. Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study[J]. Biomedical and Environmental Sciences, 2016, 29(6): 398-407. doi: 10.3967/bes2016.052

目录

    /

    返回文章
    返回