Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology

YAN Wei,  ZHAO ZhenMin,  ZHANG LiLi,  WANG DunMei,  YAN Li,  YIN NingBei,  WU Di,  ZHANG Feng

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文章导航 > Biomedical and Environmental Sciences  > 2011 >  24(4): 364-373
YAN Wei, ZHAO ZhenMin, ZHANG LiLi, WANG DunMei, YAN Li, YIN NingBei, WU Di, ZHANG Feng. Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology[J]. Biomedical and Environmental Sciences, 2011, 24(4): 364-373. doi: 10.3967/0895-3988.2011.04.007
Citation: YAN Wei, ZHAO ZhenMin, ZHANG LiLi, WANG DunMei, YAN Li, YIN NingBei, WU Di, ZHANG Feng. Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology[J]. Biomedical and Environmental Sciences, 2011, 24(4): 364-373. doi: 10.3967/0895-3988.2011.04.007
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doi: 10.3967/0895-3988.2011.04.007
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Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology

  • Plastic Surgery Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100144 China

  • CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China

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  • 刊出日期:  2011-08-20

Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology

doi: 10.3967/0895-3988.2011.04.007
  • 刊出日期: 2011-08-20

摘要: Objective Estrogens play an important role in intrinsic skin aging.The associated changes in global gene expression are poorly understood.Methods We used the Illumina microarray platform to obtain comprehensive gene expression profiles in female Chinese Han skin,and confirmed the data by quantitative real-time PCR (Q-RT-PCR).Results We found 244 genes significantly related to estrogen-associated intrinsic skin aging,and some of these genes were confirmed by Q-RT-PCR.We also performed functional analysis by both Gene Ontology annotation and enrichment of the Kyoto Encyclopedia of Genes and Genomes (KEGG)pathways database.The functional analysis revealed 11 biological pathways (including the KEGG pathways,the mitogen-activated protein kinase signaling pathway and metabolic pathways),that were associated with multiple cellular functions which may be involved in intrinsic skin aging.Conclusion This study suggests that estrogen-associated intrinsic skin aging is a complicated biological process involving many genes and pathways.

English Abstract

YAN Wei, ZHAO ZhenMin, ZHANG LiLi, WANG DunMei, YAN Li, YIN NingBei, WU Di, ZHANG Feng. Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology[J]. Biomedical and Environmental Sciences, 2011, 24(4): 364-373. doi: 10.3967/0895-3988.2011.04.007
Citation: YAN Wei, ZHAO ZhenMin, ZHANG LiLi, WANG DunMei, YAN Li, YIN NingBei, WU Di, ZHANG Feng. Identification of Estrogen-associated Intrinsic Aging Genes in Chinese Han Female Skin by cDNA Microarray Technology[J]. Biomedical and Environmental Sciences, 2011, 24(4): 364-373. doi: 10.3967/0895-3988.2011.04.007
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