ZHANG Wen; YU Wei Wen; LIU Di; LI Ming; DU Peng Cheng; WU Yi Lei; George F.GAO

doi:10.3967/0895-3988.2013.07.015

T4SP: A Novel Tool and Database for Type Ⅳ Secretion Systems in Bacterial Genomes

ZHANG Wen, YU Wei Wen, LIU Di, LI Ming, DU Peng Cheng, WU Yi Lei, George F.GAO

文章导航 > Biomedical and Environmental Sciences > 2013 > 26(7): 614-617

ZHANG Wen, YU Wei Wen, LIU Di, LI Ming, DU Peng Cheng, WU Yi Lei, George F.GAO. T4SP: A Novel Tool and Database for Type Ⅳ Secretion Systems in Bacterial Genomes[J]. Biomedical and Environmental Sciences, 2013, 26(7): 614-617. doi: 10.3967/0895-3988.2013.07.015

Citation:

ZHANG Wen, YU Wei Wen, LIU Di, LI Ming, DU Peng Cheng, WU Yi Lei, George F.GAO. T4SP: A Novel Tool and Database for Type Ⅳ Secretion Systems in Bacterial Genomes[J]. Biomedical and Environmental Sciences, 2013, 26(7): 614-617. doi: 10.3967/0895-3988.2013.07.015

doi: 10.3967/0895-3988.2013.07.015

T4SP: A Novel Tool and Database for Type Ⅳ Secretion Systems in Bacterial Genomes

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China
Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Department of Microbiology, Third Military Medical University,Chongqing 400038, China
CAS Key laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China;Beijing Institute of Life Science, Chinese Academy of Sciences;Chinese Center for Disease Control and Prevention, Beijing, China

摘要: Secretion systems,which can mediate the macromolecules to pass across cellular membranes,are essential for virulent and genetic material exchange among bacterial species[1].Type Ⅳ secretion system (T4SS) is one of the secretion systems and it usually consists of 12 genes:VirB1,VirB2...VirB11,and VirD4[2].The structure and molecular mechanisms of these genes have been well analyzed in Gram-negative strains[3] and Gram-positive strains were once believed to be lack of T4SS.However,some recent studies revealed that one or more virB/D genes also exist in some kinds of Gram-positive bacteria and play similar role,and form a T4SS-like system[3].The VirB1-like,VirB4,VirB6,and VirD4 genes were identified in the chromosome of Gram-positive bacterium Streptococcus suis in our previous studies and their role as important mobile elements for horizontal transfer to recipients in an 89 K pathogenicity island (PAI) was demonstrated[4-5].However,their structure and molecular mechanisms in other strains,especially in Gram-positive strains,are remained unclear.
- /
- molecular mechanisms /
- pathogenicity island

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T4SP: A Novel Tool and Database for Type Ⅳ Secretion Systems in Bacterial Genomes

doi: 10.3967/0895-3988.2013.07.015

刊出日期: 2013-07-20

关键词:

molecular mechanisms /

pathogenicity island

摘要: Secretion systems,which can mediate the macromolecules to pass across cellular membranes,are essential for virulent and genetic material exchange among bacterial species[1].Type Ⅳ secretion system (T4SS) is one of the secretion systems and it usually consists of 12 genes:VirB1,VirB2...VirB11,and VirD4[2].The structure and molecular mechanisms of these genes have been well analyzed in Gram-negative strains[3] and Gram-positive strains were once believed to be lack of T4SS.However,some recent studies revealed that one or more virB/D genes also exist in some kinds of Gram-positive bacteria and play similar role,and form a T4SS-like system[3].The VirB1-like,VirB4,VirB6,and VirD4 genes were identified in the chromosome of Gram-positive bacterium Streptococcus suis in our previous studies and their role as important mobile elements for horizontal transfer to recipients in an 89 K pathogenicity island (PAI) was demonstrated[4-5].However,their structure and molecular mechanisms in other strains,especially in Gram-positive strains,are remained unclear.