Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice

TAN Long YANG Hong Peng PANG Wei LU Hao HU Yan Dan LI Jing LU Shi Jun ZHANG Wan Qi JIANG Yu Gang

TAN Long, YANG Hong Peng, PANG Wei, LU Hao, HU Yan Dan, LI Jing, LU Shi Jun, ZHANG Wan Qi, JIANG Yu Gang. Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice[J]. Biomedical and Environmental Sciences, 2014, 27(3): 186-196. doi: 10.3967/bes2014.007
Citation: TAN Long, YANG Hong Peng, PANG Wei, LU Hao, HU Yan Dan, LI Jing, LU Shi Jun, ZHANG Wan Qi, JIANG Yu Gang. Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice[J]. Biomedical and Environmental Sciences, 2014, 27(3): 186-196. doi: 10.3967/bes2014.007

doi: 10.3967/bes2014.007
基金项目: This research was supported by the grant of National Natural Science Foundation of Tianjin (09JCYBJC12900)

Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice

Funds: This research was supported by the grant of National Natural Science Foundation of Tianjin (09JCYBJC12900)
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  • 刊出日期:  2014-03-20

Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice

doi: 10.3967/bes2014.007
    基金项目:  This research was supported by the grant of National Natural Science Foundation of Tianjin (09JCYBJC12900)

摘要: Objective To investigate whether the antioxidation and the regulation on the Extracellular Regulated Protein Kinases (ERK) signaling pathway are involved in the protective effects of blueberry on central nervous system.
Methods 30 Senescence-accelerated mice prone 8 (SAMP8) mice were divided into three groups and treated with normal diet, blueberry extracts (200 mg/kg·bw/day) and cyaniding-3-O-galactoside (Cy-3-GAL) (50 mg/kg·bw/day) from blueberry for 8 weeks. 10 SAMR1 mice were set as control group. The capacity of spatial memory was assessed by Passive avoidance task and Morris water maze. Histological analyses on hippocampus were completed. Malondialdehyde (MDA) levels, Superoxide Dismutase (SOD) activity and the expression of ERK were detected.
Results Both Cy-3-GAL and blueberry extracts were shown effective functions to relieve cellular injury, improve hippocampal neurons survival and inhibit the pyramidal cell layer damage. Cy-3-GAL and blueberry extracts also increased SOD activity and reduced MDA content in brain tissues and plasma, and increased hippocampal phosphorylated ERK (p-ERK) expression in SAMP8 mice. Further more, the passive avoidance task test showed that both the latency time and the number of errors were improved by Cy-3-GAL treatment, and the Morris Water Maze test showed significant decreases of latency were detected by Cy-3-GAL and blueberry extracts treatment on day 4.
Conclusion Blueberry extracts may reverse the declines of cognitive and behavioral function in the ageing process through several pathways, including enhancing the capacity of antioxidation, altering stress signaling. Cy-3-GAL may be an important active ingredient for these biological effects.

English Abstract

TAN Long, YANG Hong Peng, PANG Wei, LU Hao, HU Yan Dan, LI Jing, LU Shi Jun, ZHANG Wan Qi, JIANG Yu Gang. Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice[J]. Biomedical and Environmental Sciences, 2014, 27(3): 186-196. doi: 10.3967/bes2014.007
Citation: TAN Long, YANG Hong Peng, PANG Wei, LU Hao, HU Yan Dan, LI Jing, LU Shi Jun, ZHANG Wan Qi, JIANG Yu Gang. Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice[J]. Biomedical and Environmental Sciences, 2014, 27(3): 186-196. doi: 10.3967/bes2014.007

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