Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children

CHAO Hong ZHANG Yu Fu LIU Peng HAN Yun Feng LIU Shou Jun

CHAO Hong, ZHANG Yu Fu, LIU Peng, HAN Yun Feng, LIU Shou Jun. Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children[J]. Biomedical and Environmental Sciences, 2016, 29(6): 391-397. doi: 10.3967/bes2016.051
Citation: CHAO Hong, ZHANG Yu Fu, LIU Peng, HAN Yun Feng, LIU Shou Jun. Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children[J]. Biomedical and Environmental Sciences, 2016, 29(6): 391-397. doi: 10.3967/bes2016.051

doi: 10.3967/bes2016.051

Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children

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  • 刊出日期:  2016-06-20

Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children

doi: 10.3967/bes2016.051

摘要: Objective To assess the effect of different levels of salt iodine content on thyroid volume (ThV) distribution using data from the 1999, 2011, and 2014 Chinese national iodine deficiency disorder (IDD) surveys.
Methods Probability proportion to size (PPS) sampling method was used to obtain a representative national sample of 34,547, 38,932, and 47,188 Chinese children aged 8-10 years in 1999, 2011, and 2014 Chinese national IDD surveys, respectively. The iodine content in household iodized salt and urinary iodine concentration were measured and thyroid ultrasound examination was performed. The data were analyzed by SAS software using histograms and box plots. The skewness and kurtosis were calculated for testing the normality of ThV.
Results The median iodine content in household iodized salt dropped from 42.30 mg/kg in 1999 to 25.00 mg/kg in 2014. The median urinary iodine concentration of children aged 8-10 years decreased from 306.0μg/L in 1999 to 197.9μg/L in 2014. The median and interquartile range (IQR) of ThV in 1999, 2011, and 2014 surveys were 3.44 mL and 1.50 mL, 2.60 mL and 1.37 mL, 2.63 mL and 1.25 mL, respectively. The skewness and kurtosis of ThV distribution in 1999, 2011, and 2014 surveys were 1.34 and 5.84, 0.98 and 3.54, 1.27 and 5.49, respectively.
Conclusion With reduced salt iodization levels, the median urinary iodine concentration and median ThV of children decreased significantly, and the symmetry of the ThV distribution improved.

English Abstract

CHAO Hong, ZHANG Yu Fu, LIU Peng, HAN Yun Feng, LIU Shou Jun. Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children[J]. Biomedical and Environmental Sciences, 2016, 29(6): 391-397. doi: 10.3967/bes2016.051
Citation: CHAO Hong, ZHANG Yu Fu, LIU Peng, HAN Yun Feng, LIU Shou Jun. Relationship between Iodine Content in Household Iodized Salt and Thyroid Volume Distribution in Children[J]. Biomedical and Environmental Sciences, 2016, 29(6): 391-397. doi: 10.3967/bes2016.051

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