DENG Xin Ru; ZHANG Yin Fei; WANG Tian Ge; XU Bai Hui; SUN Ji Chao; ZHAO Lie Bin; XU Min; CHEN Yu Hong; WANG Wei Qing; BI Yu Fang; LU Jie Li

doi:10.3967/bes2014.091

doi: 10.3967/bes2014.091

基金项目: the Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health(1994DP131044)%National Nature Science Foundation of China(81170739,81170719,81222008,81370960)%Shanghai New Excel ent Youth Program(XYQ2011009)%Shanghai Health Bureau(2011293)%EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)%Shanghai Shen Kang Hospital Development Center(SHDC12012301)

Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China
Department of Endocrinology and Metabolism, Central Hospital of Jiading District, Shanghai 201800, China
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Funds: the Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health(1994DP131044)%National Nature Science Foundation of China(81170739,81170719,81222008,81370960)%Shanghai New Excel ent Youth Program(XYQ2011009)%Shanghai Health Bureau(2011293)%EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)%Shanghai Shen Kang Hospital Development Center(SHDC12012301)

摘要: Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects.
Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s (the upper quartile) either side.
Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level (P<0.05). The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile (26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P<0.0001). Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile (OR=1.32, 95%CI:1.08-1.60).
Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
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Abstract: Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects.
Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s (the upper quartile) either side.
Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level (P<0.05). The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile (26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P<0.0001). Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile (OR=1.32, 95%CI:1.08-1.60).
Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
- Calcium /
- Brachial-ankle pulse wave velocity /
- Vascular stiffness

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doi: 10.3967/bes2014.091

Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

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Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

doi: 10.3967/bes2014.091

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Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

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doi: 10.3967/bes2014.091

Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

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Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

doi: 10.3967/bes2014.091

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Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese

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