YU Bo; WU HongYing; LI Fang; GONG Jie; ZHOU DunJin; ZHANG ZhiFeng; YANG XiaoGuang; HUANG ZhenWu

doi:10.3967/0895-3988.2011.03.006

doi: 10.3967/0895-3988.2011.03.006

基金项目: the Ministry of Health and Ministry of Science and Technology(2008BAI58B02)%National Nature Science Foundation(30571573)

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China
Department of Radiography, Union Hospital, Huazhong University of Science & Technology, Wuhan 430022, Hubei, China
Wuhan Regional Center for Disease Control and Prevention, Wuhan 430024, Hubei, China

Funds: the Ministry of Health and Ministry of Science and Technology(2008BAI58B02)%National Nature Science Foundation(30571573)

摘要: Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO3) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD3, and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
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Abstract: Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO3) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD3, and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
- FokI VDR genotype /
- Calcium supplementation /
- Bone mineral accretion after weaning /
- Chinese women /
- Low dietary calcium intake

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doi: 10.3967/0895-3988.2011.03.006

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

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Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

doi: 10.3967/0895-3988.2011.03.006

English Abstract

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

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doi: 10.3967/0895-3988.2011.03.006

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

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Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

doi: 10.3967/0895-3988.2011.03.006

English Abstract

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

全文HTML

目录