YU Bo; WU HongYing; LI Fang; GONG Jie; ZHOU DunJin; ZHANG ZhiFeng; YANG XiaoGuang; HUANG ZhenWu

doi:10.3967/0895-3988.2011.03.006

doi: 10.3967/0895-3988.2011.03.006

基金项目: the Ministry of Health and Ministry of Science and Technology(2008BAI58B02)%National Nature Science Foundation(30571573)

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China
Department of Radiography, Union Hospital, Huazhong University of Science & Technology, Wuhan 430022, Hubei, China
Wuhan Regional Center for Disease Control and Prevention, Wuhan 430024, Hubei, China

Funds: the Ministry of Health and Ministry of Science and Technology(2008BAI58B02)%National Nature Science Foundation(30571573)

摘要: Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO3) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD3, and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
- /
- /
- /
- /
Abstract: Objective To investigate the effect of calcium supplementation on bone mineral density (BMD) in Chinese women with different FokI vitamin D receptor (VDR) genotypes (FF, Ff, and ff) after weaning or resumption of menstruation during lactation.Methods A total of 40 subjects with the same FokI VDR genotype were randomly divided into two groups: one received calcium tablet (600 mg once daily as CaCO3) and the other placebo tablet once daily for 1 year. At baseline, BMD was measured by dual-energy X-ray absorptiometry at lumbar spine (L2-L4) and at left hip whereas serum PICP, serum OC, and urinary CTX, serum 25(OH)VitD3, and serum estradiol were measured at weaning and 1 year thereafter.Results After the intervention, BMD at lumbar spine and at left hip increased significantly in all these women with a trend among different FokI VDR genotypes such as FF > Ff > ff (P<0.05, <0.01, and <0.001, respectively). BMD at lumbar spine in women with FF VDR genotype increased much more rapidly than in those with ff VDR genotype (P<0.05). Compared with the control group women with the FF genotype regained more BMD after calcium supplementation (P<0.05).Conclusion Daily calcium 600 mg supplementation has beneficial effect on the bone health of women with FF VDR genotype.
- FokI VDR genotype /
- Calcium supplementation /
- Bone mineral accretion after weaning /
- Chinese women /
- Low dietary calcium intake

[1]	Xiaoyun Shan, Yuting Li, Xiayu Zhao, Yichun Hu, Siran Li, Huidi Zhang, Yang Cao, Rui Wang, Lichen Yang. Threshold-Effect Associations of Serum 25-hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age . Biomedical and Environmental Sciences, 2025, 38(4): 433-446. doi: 10.3967/bes2024.151
[2]	Xiaobing Liu, Jun Wang, Yajie Li, Hongxing Tan, Deqian Mao, Yanyan Liu, Weidong Li, Wei Yu, Junan Yan, Jianhua Piao, Chongzheng Guo, Xiaoli Liu, Xiaoguang Yang. Re-exploration for Dietary Iodine Intake in Chinese Adults Using the Obligatory Iodine Loss Hypothesis . Biomedical and Environmental Sciences, 2025, 38(): 1-9. doi: 10.3967/bes2025.017
[3]	SUN Rong, QIAN Ting Ting, LIU Lan Chun, ZHAO Meng, CHE Wen Jing, ZHANG Ling, LI Wei Dong, JIA Qing Zhen, WANG Jian Hui, LI Jin Shu, CHEN Zhi Hui, ZHANG Bi Yun, LIU Peng. Effect of Iodine Supplementation on Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study . Biomedical and Environmental Sciences, 2022, 35(7): 641-647. doi: 10.3967/bes2022.083
[4]	LI Li, ZHANG Bing, WANG Hui Jun, OUYANG Yi Fei, HUANG Fei Fei, WANG Yun, ZHANG Ji Guo, SU Chang, DU Wen Wen, JIA Xiao Fang, JIANG Hong Ru, WANG Zhi Hong. Sociodemographic Factors Associated with Dietary Intake of Thiamine, Riboflavin, and Niacin among Chinese Adults in 2015 . Biomedical and Environmental Sciences, 2020, 33(9): 660-669. doi: 10.3967/bes2020.087
[5]	HU Shao Hua, WANG Hui, LU Li, ZHOU Hong Mei, WANG Chang Zhen, GAO Ya Bing, DONG Ji, PENG Rui Yun. Real-time Assessment of Cytosolic, Mitochondrial, and Nuclear Calcium Levels Change in Rat Pheochromocytoma Cells during Pulsed Microwave Exposure Using a Genetically Encoded Calcium Indicator . Biomedical and Environmental Sciences, 2017, 30(12): 927-931. doi: 10.3967/bes2017.125
[6]	YAN Jing, ZHENG Yu Zhi, CAO Lu Jia, LIU Yu Yan, LI Wen, HUANG Guo Wei. Periconceptional Folic Acid Supplementation in Chinese Women:A Cross-sectional Study . Biomedical and Environmental Sciences, 2017, 30(10): 737-748. doi: 10.3967/bes2017.099
[7]	XU Qing, GAO Zhi Ying, LI Li Ming, WANG Lu, ZHANG Qian, TENG Yue, ZHAO Xia, GE Sheng, JING Hong Jiang, YANG Yong Tao, LIU Xiao Jun, LYU Chun Jian, MAO Lun, YU Xiao Ming, LIU Ying Hua, KONG Ai Jing, YANG Xue Yan, LIU Zhao, ZHANG Yong, WANG Jin, ZHANG Xin Sheng, XUE Chang Yong, LU Yan Ping. The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women . Biomedical and Environmental Sciences, 2016, 29(1): 1-11. doi: 10.3967/bes2016.001
[8]	JIA Hai Xian, HAN Jun Hua, LI Hu Zhong, LIANG Dong, DENG Tao Tao, CHANG Su Ying. Mineral Intake in Urban Pregnant Women from Base Diet, Fortified Foods, and Food Supplements:Focus on Calcium, Iron, and Zinc . Biomedical and Environmental Sciences, 2016, 29(12): 898-901. doi: 10.3967/bes2016.120
[9]	DENG Xin Ru, ZHANG Yin Fei, WANG Tian Ge, XU Bai Hui, SUN Ji Chao, ZHAO Lie Bin, XU Min, CHEN Yu Hong, WANG Wei Qing, BI Yu Fang, LU Jie Li. Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese . Biomedical and Environmental Sciences, 2014, 27(8): 594-600. doi: 10.3967/bes2014.091
[10]	ZHOU Ji Chang, ZHU Yu Mei, GUO Ping, CHEN Zheng, XIE Feng Zhu, LIU Xiao Li, HE Shan. Serum 25(OH)D and Lipid Levels in Chinese Obese and Normal Weight Males before and after Oral Vitamin D Supplementation . Biomedical and Environmental Sciences, 2013, 26(10): 801-807. doi: 10.3967/bes2013.003
[11]	ZHOU Qian, ZHANG Chao Lin, MA Dan Dan, LI Meng Jie, ZHU Wen Li, WANG Na, ZHANG Wei Rui. Effect of Different Calcium Supplements on Bone Metabolism in Rats . Biomedical and Environmental Sciences, 2013, 26(8): 675-679. doi: 10.3967/0895-3988.2013.08.007
[12]	MA Ka Ying, LIANG Yin Tong, CHEN Jing Nan, JIANG Yue, KWAN Kin Ming, PENG Cheng, JIAO Rui, ZUO Yuan Yuan, HUANG Yu, CHEN Zhen Yu. Dietary Calcium Decreases Plasma Cholesterol Level only in Female but not in Male Hamster Fed a High Cholesterol Diet . Biomedical and Environmental Sciences, 2012, 25(4): 392-398. doi: 10.3967/0895-3988.2012.04.003
[13]	WANG Ou, NIE Min, HU Ying Ying, ZHANG Kui, LI Wei, PING Fan, LIU Jun Tao, CHEN Li Meng, XING Xiao Ping. Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women . Biomedical and Environmental Sciences, 2012, 25(4): 399-406. doi: 10.3967/0895-3988.2012.04.004
[14]	SUI Hai Xia, LI Jian Wen, MAO Wei Feng, ZHU Jiang Hui, HE Yu Na, SONG Xiao Yu, MA Ning, ZHANG Lei, LIU Sa Na, LIU Zhao Ping, LI Feng Qin. Dietary Iodine Intake in the Chinese Population . Biomedical and Environmental Sciences, 2011, 24(6): 617-623. doi: 10.3967/0895-3988.2011.06.005
[15]	. Relatively High Bone Mineral Density in Chinese Adolescent Dancers Despite Lower Energy Intake and Menstrual Disorder . Biomedical and Environmental Sciences, 2010, 23(2): 130-136.
[16]	LI-CHEN YANG, YAN LAN, JING HU, YAN-HUA YANG, QIAN ZHANG, JIAN-HUA PIAO. Correlation of Serum Leptin Level with Bone Mineral Density and Bone Turnover Markers in Chinese Adolescent Dancers . Biomedical and Environmental Sciences, 2009, 22(5): 369-373.
[17]	LI-CHEN YANG, QIAN ZHANG, JIA-NHUA PIAO, ZHENG-WU HUANG, XIAO-QI HU, GUAN-SHENG MA. Association of Estrogen Receptor-α Gene Pvull Polymorphisms with the Effect of Calcium Supplementation on Skeletal Development in Chinese Pubertal Girls . Biomedical and Environmental Sciences, 2009, 22(6): 480-487.
[18]	JUN HE, JIAN-FENG CHEN, RU LIU, LIN SONG, HEBRON C. CHANG, XIN-RU WANG. Fenvalerate-induced Alterations in Calcium Homeostasis in Rat Ovary . Biomedical and Environmental Sciences, 2006, 19(1): 15-20.
[19]	Jaya Singh, Krishna P.Gupta. Calcium Glucarate Prevents Tumor Formation in Mouse Skin . Biomedical and Environmental Sciences, 2003, 16(1): 9-16.
[20]	YANG YUE-XIN, CHEN XUE-CUN, LIU Jian-yu, Pan Li-mei, YAN HUANI-CHENG, XU QING-MEI. Effect of Zinc Intake on Fetal and Infant Growth Among Chinese Pregnant and Lactating Women . Biomedical and Environmental Sciences, 2000, 13(4): 280-286.

点击查看大图

计量

文章访问数: 1591
HTML全文浏览量: 371
PDF下载量: 41
被引次数: 0

doi: 10.3967/0895-3988.2011.03.006

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

计量

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

doi: 10.3967/0895-3988.2011.03.006

English Abstract

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

全文HTML

目录

doi: 10.3967/0895-3988.2011.03.006

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

计量

出版历程

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

doi: 10.3967/0895-3988.2011.03.006

English Abstract

Change of BMD after Weaning or Resumption of Menstruation in Chinese Women with Different FokI VDR-genotypes: A Randomized, Placebo-controlled, Calcium Supplementation Trial

全文HTML

目录