TIAN Yun Fan; ZHOU Yi Peng; ZHONG Chong Ke; BUREN Batu; XU Tian; LI Hong Mei; ZHANG Ming Zhi; WANG Ai Li; ZHANG Yong Hong

doi:10.3967/bes2016.062

doi: 10.3967/bes2016.062

基金项目: This study was supported by the National Natural Science Foundation of China(grant .30972531 and 81320108026)%a project of the Priority Academic Program Development of Jiangsu Higher Education Institutions

C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
Department of Epidemiology, Tongliao Center for Disease Prevention and Control, Tongliao 028005, Inner Mongolia, China

Funds: This study was supported by the National Natural Science Foundation of China(grant .30972531 and 81320108026)%a project of the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘要: Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
Methods From June 2003 to July 2012, 2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation. All the participants were divided into four subgroups according to C-reactive protein (CRP) level and ApoB/ApoA-1 ratio. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the IS and CHD events in all the subgroups.
Results The HRs (95% CI) for IS and CHD were 1.33 (0.84-2.12), 1.14 (0.69-1.88), and 1.91 (1.17-3.11) in the ‘low CRP level with high ApoB/ApoA-1’, ‘high CRP level with low ApoB/ApoA-1’, and ‘high CRP level with high ApoB/ApoA-1’ subgroups, respectively, in comparison with the ‘low CRP level with low ApoB/ApoA-1’ subgroup. The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1’ subgroup, with statistical significance.
Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population. This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.
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Abstract: Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
Methods From June 2003 to July 2012, 2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation. All the participants were divided into four subgroups according to C-reactive protein (CRP) level and ApoB/ApoA-1 ratio. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the IS and CHD events in all the subgroups.
Results The HRs (95% CI) for IS and CHD were 1.33 (0.84-2.12), 1.14 (0.69-1.88), and 1.91 (1.17-3.11) in the ‘low CRP level with high ApoB/ApoA-1’, ‘high CRP level with low ApoB/ApoA-1’, and ‘high CRP level with high ApoB/ApoA-1’ subgroups, respectively, in comparison with the ‘low CRP level with low ApoB/ApoA-1’ subgroup. The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1’ subgroup, with statistical significance.
Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population. This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.
- C-reactive protein /
- Apolipoprotein B-to-apolipoprotein A-1 ratio /
- Ischemic stroke /
- Coronary heart disease

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doi: 10.3967/bes2016.062

C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

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C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

doi: 10.3967/bes2016.062

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C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

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doi: 10.3967/bes2016.062

C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

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C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

doi: 10.3967/bes2016.062

English Abstract

C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

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