Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China

WANG Sheng Fen ZHOU Yang PANG Yu ZHENG Hui Wen ZHAO Yan Lin

WANG Sheng Fen, ZHOU Yang, PANG Yu, ZHENG Hui Wen, ZHAO Yan Lin. Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China[J]. Biomedical and Environmental Sciences, 2016, 29(2): 91-98. doi: 10.3967/bes2016.010
Citation: WANG Sheng Fen, ZHOU Yang, PANG Yu, ZHENG Hui Wen, ZHAO Yan Lin. Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China[J]. Biomedical and Environmental Sciences, 2016, 29(2): 91-98. doi: 10.3967/bes2016.010

doi: 10.3967/bes2016.010
基金项目: a research grant from the National Science & Technology Major Project(2014ZX10003001001)%(2014ZX10003002)

Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China

Funds: a research grant from the National Science & Technology Major Project(2014ZX10003001001)%(2014ZX10003002)
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出版历程
  • 刊出日期:  2016-02-20

Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China

doi: 10.3967/bes2016.010
    基金项目:  a research grant from the National Science & Technology Major Project(2014ZX10003001001)%(2014ZX10003002)

摘要: ObjectiveTo investigatetheprevalence of primary drug-resistant tuberculosis (TB) and associated risk factors in China.We also explored factors contributing tothe transmission of multidrug-resistant tuberculosis (MDR-TB). MethodsA total of 2794 representative,Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TBwere analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. ResultsAmong 2794Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2%andthe prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs.The93 primary MDR-TB isolates were classified into six sublineages, of which, 75 (80.6%) isolates were the RD105-deleted Beijing lineage.The largest sublineage included 65 (69.9%) isolates with concurrent deletions of RD105, RD207, and RD181.Twenty-nine (31.2%) primary MDR strains grouped in clusters;MDR isolates in clusters were more likely to have S531LrpoBmutation. ConclusionThis study indicates that primary drug-resistantTBand MDR-TBstrains are prevalent in China,and multiplemeasures should be taken toaddress drug-resistant TB.

English Abstract

WANG Sheng Fen, ZHOU Yang, PANG Yu, ZHENG Hui Wen, ZHAO Yan Lin. Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China[J]. Biomedical and Environmental Sciences, 2016, 29(2): 91-98. doi: 10.3967/bes2016.010
Citation: WANG Sheng Fen, ZHOU Yang, PANG Yu, ZHENG Hui Wen, ZHAO Yan Lin. Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China[J]. Biomedical and Environmental Sciences, 2016, 29(2): 91-98. doi: 10.3967/bes2016.010

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