The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory

ZHAO Ya Li LI Ying Xian MA Hong Bo LI Dong LI Hai Liang JIANG Rui KAN Guang Han YANG Zhen Zhong HUANG Zeng Xin

ZHAO Ya Li, LI Ying Xian, MA Hong Bo, LI Dong, LI Hai Liang, JIANG Rui, KAN Guang Han, YANG Zhen Zhong, HUANG Zeng Xin. The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory[J]. Biomedical and Environmental Sciences, 2015, 28(8): 558-570. doi: 10.3967/bes2015.080
Citation: ZHAO Ya Li, LI Ying Xian, MA Hong Bo, LI Dong, LI Hai Liang, JIANG Rui, KAN Guang Han, YANG Zhen Zhong, HUANG Zeng Xin. The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory[J]. Biomedical and Environmental Sciences, 2015, 28(8): 558-570. doi: 10.3967/bes2015.080

doi: 10.3967/bes2015.080
基金项目: This research was supported by the Foundation of Astronaut Research and Training Center of China (SN 02-3)

The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory

Funds: This research was supported by the Foundation of Astronaut Research and Training Center of China (SN 02-3)
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出版历程
  • 刊出日期:  2015-08-20

The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory

doi: 10.3967/bes2015.080
    基金项目:  This research was supported by the Foundation of Astronaut Research and Training Center of China (SN 02-3)

摘要: Objective To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfunction.
Methods Mice were exposed to whole body 2100 MHz microwaves with specific absorption rates (SARs) of 0.45 W/kg, 1.8 W/kg, and 3.6 W/kg for 1 hour daily for 8 weeks. Differentially expressing genes in the brains were screened using high-density oligonucleotide arrays, with genes showing more significant differences further confirmed by RT-PCR.
Results The gene chip results demonstrated that 41 genes (0.45 W/kg group), 29 genes (1.8 W/kg group), and 219 genes (3.6 W/kg group) were differentially expressed. GO analysis revealed that these differentially expressed genes were primarily involved in metabolic processes, cellular metabolic processes, regulation of biological processes, macromolecular metabolic processes, biosynthetic processes, cellular protein metabolic processes, transport, developmental processes, cellular component organization, etc. KEGG pathway analysis showed that these genes are mainly involved in pathways related to ribosome, Alzheimer's disease, Parkinson's disease, long-term potentiation, Huntington's disease, and Neurotrophin signaling. Construction of a protein interaction network identified several important regulatory genes including synbindin (sbdn), Crystallin (CryaB), PPP1CA, Ywhaq, Psap, Psmb1, Pcbp2, etc., which play important roles in the processes of learning and memory.
Conclusion Long-term, low-level microwave exposure may inhibit learning and memory by affecting protein and energy metabolic processes and signaling pathways relating to neurological functions or diseases.

English Abstract

ZHAO Ya Li, LI Ying Xian, MA Hong Bo, LI Dong, LI Hai Liang, JIANG Rui, KAN Guang Han, YANG Zhen Zhong, HUANG Zeng Xin. The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory[J]. Biomedical and Environmental Sciences, 2015, 28(8): 558-570. doi: 10.3967/bes2015.080
Citation: ZHAO Ya Li, LI Ying Xian, MA Hong Bo, LI Dong, LI Hai Liang, JIANG Rui, KAN Guang Han, YANG Zhen Zhong, HUANG Zeng Xin. The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory[J]. Biomedical and Environmental Sciences, 2015, 28(8): 558-570. doi: 10.3967/bes2015.080

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