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Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
(30 day view times: 30)
2023, 36(8): 669-701.
doi: 10.3967/bes2023.106
In the past 30 years, the accessibility and quality index of medical care have made remarkable progress in China, ranking the first among middle-income countries. Many cardiovascular technologies are at or near the world's leading level, and significant progress has been achieved in China solving the problem of “treatment difficulty” of cardiovascular diseases (CVD). However, due to the prevalence of unhealthy lifestyles among Chinese residents, a huge population with CVD risk factors, accelerated population aging, and other reasons, the incidence and mortality rate of CVD are still increasing, and the turning point of the decline in disease burden has not appeared yet in China. In terms of proportions of disease mortality among urban and rural residents, CVD still ranks the first. In 2020, CVD accounted for 48.00% and 45.86% of the causes of death in rural and urban areas, respectively; two out of every five deaths were due to CVD. It is estimated that the number of current CVD patients in China is around 330 million, including 13 million stroke, 11.39 million coronary heart disease, 8.9 million heart failure, 5 million pulmonary heart disease, 4.87 million atrial fibrillation, 2.5 million rheumatic heart disease, 2 million congenital heart disease, 45.3 million peripheral artery disease, and 245 million hypertension cases. China has entered a new stage of transformation from high-speed development to high-quality development, and the prevention and control of CVD in China should also shift from previous emphasis on scale growth to strategies focusing more on strategic and key technological development in order to curb the trend of increasing incidence and mortality rates of CVD.
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Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary
(30 day view times: 18)
2022, 35(7): 573-603.
doi: 10.3967/bes2022.079
In 2019, cardiovascular disease (CVD) accounted for 46.74% and 44.26% of all deaths in rural and urban areas, respectively. Two out of every five deaths were due to CVD. It is estimated that about 330 million patients suffer from CVD in China. The number of patients suffering from stroke, coronary heart disease, heart failure, pulmonary heart disease, atrial fibrillation, rheumatic heart disease, congenital heart disease, lower extremity artery disease and hypertension are 13.00 million, 11.39 million, 8.90 million, 5.00 million, 4.87 million, 2.50 million, 2.00 million, 45.30 million, and 245.00 million, respectively. Given that China is challenged by the dual pressures of population aging and steady rise in the prevalence of metabolic risk factors, the burden caused by CVD will continue to increase, which has set new requirements for CVD prevention and treatment and the allocation of medical resources in China. It is important to reduce the prevalence through primary prevention, increase the allocation of medical resources for CVD emergency and critical care, and provide rehabilitation services and secondary prevention to reduce the risk of recurrence, re-hospitalization and disability in CVD survivors. The number of people suffering from hypertension, dyslipidemia and diabetes in China has reached hundreds of millions. Since blood pressure, blood lipids, and blood glucose levels rise mostly insidiously, vascular disease or even serious events such as myocardial infarction and stroke often already occured at the time of detection in this population. Hence, more strategies and tasks should be taken to prevent risk factors such as hypertension, dyslipidemia, diabetes, obesity, and smoking, and more efforts should be made in the assessment of cardiovascular health status and the prevention, treatment, and research of early pathological changes.
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Bone Injury and Fracture Healing Biology
(30 day view times: 17)
2015, 28(1): 57-71.
doi: 10.3967/bes2015.006
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Antibody Levels and Infection Status of Pertussis in the Population under Pertussis Resurgence in Guangxi in 2018: A Cross-Sectional Survey
(30 day view times: 14)
2024, 37(6): 628-638.
doi: 10.3967/bes2024.069
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Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics
(30 day view times: 12)
2022, 35(11): 1025-1037.
doi: 10.3967/bes2022.131
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Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
(30 day view times: 11)
2019, 32(8): 559-570.
doi: 10.3967/bes2019.074
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Selenium, Type-2 Diabetes, and the Possible Protective Role of Vitamin D
(30 day view times: 11)
2024, 37(6): 661-665.
doi: 10.3967/bes2024.072
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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers
(30 day view times: 11)
2024, 37(5): 445-456.
doi: 10.3967/bes2024.051
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The Association between GLP-1 Receptor-Based Agonists and the Incidence of Asthma in Patients with Type 2 Diabetes and/or Obesity: A Meta-Analysis
(30 day view times: 11)
2024, 37(6): 607-616.
doi: 10.3967/bes2024.067
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Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix
(30 day view times: 11)
2024, 37(6): 565-580.
doi: 10.3967/bes2024.064
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Predicting the Prognosis and Immunotherapeutic Response of Triple-Negative Breast Cancer by Constructing a Prognostic Model Based on CD8+ T Cell-Related Immune Genes
(30 day view times: 10)
2024, 37(6): 581-593.
doi: 10.3967/bes2024.065
13
Physical, Psychological, and Social Health Impact of Temperature Rise Due to Urban Heat Island Phenomenon and Its Associated Factors
(30 day view times: 9)
2018, 31(7): 545-550.
doi: 10.3967/bes2018.074
14
Plastic Expander-Related Gordonia Sputi Infection:Case Report and Literature Review
(30 day view times: 9)
2015, 28(6): 468-471.
doi: 10.3967/bes2015.067
15
Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing, China, in 2016: Is It Relevant?
(30 day view times: 9)
2020, 33(12): 916-924.
doi: 10.3967/bes2020.125
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Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection
(30 day view times: 9)
2024, 37(6): 647-660.
doi: 10.3967/bes2024.071
Abstract: Toxoplasma gondii (T. gondii or Tg), is an obligatory intracellular parasite with humans as its intermediate hosts. In recent years, significant correlations between T. gondii infection and schizophrenia have been reported, including the possible mediating mechanisms. Currently, mechanisms and hypotheses focus on central neurotransmitters, immunity, neuroinflammation, and epigenetics; however, the exact underlying mechanisms remain unclear. In this article, we review the studies related to T. gondii infection and schizophrenia, particularly the latest research progress. Research on dopamine (DA) and other neurotransmitters, the blood-brain barrier, inflammatory factors, disease heterogeneity, and other confounders is also discussed. In addition, we also summarized the results of some new epidemiological investigations.
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Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990−2016: Findings from the Global Burden of Disease Study 2016
(30 day view times: 9)
2020, 33(1): 1-10.
doi: 10.3967/bes2020.001
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Incidence and Associated Factors for Single and Recurrent Falls among the Elderly in an Urban Community of Beijing
(30 day view times: 8)
2014, 27(12): 939-949.
doi: 10.3967/bes2014.134
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SiO2 Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model
(30 day view times: 8)
2024, 37(6): 617-627.
doi: 10.3967/bes2024.087
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Oxidative Stress and Apoptotic Changes of Rat Cerebral Cortical NeuronsExposed to Cadmium in Vitro
(30 day view times: 8)
2012, 25(2): 172-181.
doi: 10.3967/0895-3988.2012.02.008
Objective To investigate the cytotoxic mechanism of cadmium (Cd) on cerebral cortical neurons.Methods The primary cultures of rat cerebral cortical neurons were treated with different concentrations of cadmium acetate (0,5,10,and 20 μmol/L),and then the cell viability,apoptosis,ultrastructure,intracellular [Ca2+],and reactive oxygen species (ROS) levels,mitochondrial membrane potential (Δψ),activities of catalase (CAT) and superoxide dismutase (SOD) were measured.Results A progressive loss in cell viability and an increased number of apoptotic cells were observed.In addition,Cd-induced apoptotic morphological changes in cerebral cortical neurons were also demonstrated by Hoechst 33258 staining.Meanwhile,ultrastructural changes were distortion of mitochondrial cristae and an unusual arrangement.Simultaneously,elevation of intracellular [Ca2+] and ROS levels,depletion of △ψ were revealed in a dose-dependent manner during the exposure.Moreover,CAT and SOD activities in the living cells increased significantly.Conclusion Exposure of cortical neurons to different doses of Cd led to cellular death,mediated by an apoptotic mechanism,and the apoptotic death induced by oxidative stress may be a potential reason.And the disorder of intracellular homeostasis caused by oxidative stress and mitochondrial dysfunction may be a trigger for apoptosis in cortical neurons.